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Mouse Anti-NR2E1 Recombinant Antibody (4D2) (CBMAB-N3399-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4D2
Antibody Isotype
IgG2a, κ
Application
ELISA, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nuclear receptor subfamily 2, group E, member 1
Introduction
The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Entrez Gene ID
7101
UniProt ID
Q9Y466
Alternative Names
Nuclear Receptor Subfamily 2 Group E Member 1; Protein Tailless Homolog; Nuclear Receptor TLX; TLX; TLL; Nuclear Receptor Subfamily 2, Group E, Member 1; Tailes-Related Receptor; XTLL; HTll;
Function
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity).
May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity).
May be involved in retinoic acid receptor (RAR) regulation in retinal cells.
Biological Process
Aggressive behaviorIEA:Ensembl
Amygdala developmentIEA:Ensembl
Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Anterior commissure morphogenesisIEA:Ensembl
Behavioral fear responseIEA:Ensembl
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Cell fate commitmentIEA:Ensembl
Cerebral cortex neuron differentiationIEA:Ensembl
Dentate gyrus developmentIEA:Ensembl
Extracellular matrix organizationIEA:Ensembl
Forebrain generation of neuronsIEA:Ensembl
Layer formation in cerebral cortexIEA:Ensembl
Long-term synaptic potentiationIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of astrocyte differentiationIEA:Ensembl
Negative regulation of neural precursor cell proliferationIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Olfactory bulb developmentIEA:Ensembl
Positive regulation of angiogenesisIEA:Ensembl
Positive regulation of cell cycleIEA:Ensembl
Positive regulation of neural precursor cell proliferationIEA:Ensembl
Positive regulation of stem cell proliferationIEA:Ensembl
Regulation of cell migration involved in sprouting angiogenesisIEA:Ensembl
Regulation of dendrite morphogenesisIEA:Ensembl
Regulation of timing of neuron differentiationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Retina development in camera-type eyeIEA:Ensembl
Social behaviorIEA:Ensembl
Somatic stem cell population maintenanceIEA:Ensembl
Visual perceptionIEA:Ensembl
Cellular Location
Nucleus
More Infomation

Hu, R., Hameed, U. F. S., Sun, X., Moorthy, B. S., Zhang, W., Jeffrey, P. D., ... & Yuan, P. (2023). A NR2E1‐interacting peptide of LSD1 inhibits the proliferation of brain tumour initiating cells. Cell Proliferation, 56(1), e13350.

Nelczyk, A. T., Ma, L., Gupta, A. D., Gamage, H. E. V., McHenry, M. T., Henn, M. A., ... & Nelson, E. R. (2022). The nuclear receptor TLX (NR2E1) inhibits growth and progression of triple-negative breast cancer. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1868(11), 166515.

Kandel, P., Semerci, F., Mishra, R., Choi, W., Bajic, A., Baluya, D., ... & Maletic-Savatic, M. (2022). Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis. Proceedings of the National Academy of Sciences, 119(13), e2023784119.

He, G., Gu, J., Wang, H., Cheng, S., Xiong, Q., Ke, M., ... & Xu, Y. (2021). Nr2e1 deficiency aggravates insulin resistance and chronic inflammation of visceral adipose tissues in a diet-induced obese mice model. Life Sciences, 278, 119562.

Kandel, P., Semerci, F., Bajic, A., Baluya, D., Ma, L., Chen, K., ... & Maletic-Savatic, M. (2020). Oleic acid triggers hippocampal neurogenesis by binding to TLX/NR2E1. bioRxiv, 2020-10.

Wang, Y. Y., Hsu, S. H., Tsai, H. Y., & Cheng, M. C. (2020). Genetic analysis of the NR2E1 gene as a candidate gene of schizophrenia. Psychiatry Research, 293, 113386.

Xiong, Q., Wu, Y., Yang, M., Wu, G., Wang, Y., Wang, H., ... & Xu, Y. (2019). Nr2e1 ablation impairs liver glucolipid metabolism and induces inflammation, high-fat diets amplify the damage. Biomedicine & Pharmacotherapy, 120, 109503.

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For research use only. Not intended for any clinical use.

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