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Rat Anti-NFATC3 Recombinant Antibody (CBWJN-0805) (CBMAB-N2174-WJ)


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Summary

Host Animal
Rat
Specificity
Human, Mouse
Clone
CBWJN-0805
Antibody Isotype
IgG2a, κ
Application
WB

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NFATC3
Introduction
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]
Entrez Gene ID
Human4775
Mouse18021
UniProt ID
HumanQ12968
MouseP97305
Alternative Names
Nuclear Factor Of Activated T Cells 3; Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3; Nuclear Factor Of Activated T-Cells 3; NF-ATc3; NFATX; NFAT4; Nuclear Factor Of Activated T-Cells C3 Isoform IE-Xa;
Function
Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128).

Along with NFATC4, involved in embryonic heart development (By similarity).
Biological Process
Calcineurin-NFAT signaling cascade Source: GO_Central
Inflammatory response Source: ProtInc
Negative regulation of miRNA transcription Source: BHF-UCL
Negative regulation of vascular associated smooth muscle cell differentiation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Cytoplasm
Note: Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
PTM
Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin.
More Infomation

Zhao, S., Hu, Y., Yang, B., Zhang, L., Xu, M., Jiang, K., ... & Shen, J. (2024). The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3. Cell Death & Disease, 15(1), 75.

Nie, Y., Zhai, X., Li, J., Sun, A., Che, H., Christman, J. W., ... & Karpurapu, M. (2023). NFATc3 Promotes Pulmonary Inflammation and Fibrosis by Regulating Production of CCL2 and CXCL2 in Macrophages. Aging and disease, 14(4), 1441.

Tong, Y., Zhang, Z., Cheng, Y., Yang, J., Fan, C., Zhang, X., ... & Yan, D. (2022). Hypoxia-induced NFATc3 deSUMOylation enhances pancreatic carcinoma progression. Cell Death & Disease, 13(4), 413.

Zao, X., Cheng, J., Shen, C., Guan, G., Feng, X., Zou, J., ... & Chen, X. (2021). NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription. Oncoimmunology, 10(1), 1869388.

Liu, X., Guo, J. W., Lin, X. C., Tuo, Y. H., Peng, W. L., He, S. Y., ... & Liang, S. J. (2021). Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms. European Heart Journal, 42(47), 4847-4861.

Zhang, Y., Qian, X., Yang, X., Niu, R., Song, S., Zhu, F., ... & Chen, F. (2020). ASIC1a induces synovial inflammation via the Ca2+/NFATc3/RANTES pathway. Theranostics, 10(1), 247.

Lee, S. H., Kieu, C., Martin, C. E., Han, J., Chen, W., Kim, J. S., ... & Shin, K. H. (2019). NFATc3 plays an oncogenic role in oral/oropharyngeal squamous cell carcinomas by promoting cancer stemness via expression of OCT4. Oncotarget, 10(23), 2306.

Li, M., Fang, X. Z., Zheng, Y. F., Xie, Y. B., Ma, X. D., Liu, X. T., ... & Shao, D. H. (2019). Transient receptor potential vanilloid 4 is a critical mediator in LPS mediated inflammation by mediating calcineurin/NFATc3 signaling. Biochemical and biophysical research communications, 513(4), 1005-1012.

Chao, C. N., Lai, C. H., Badrealam, K. F., Lo, J. F., Shen, C. Y., Chen, C. H., ... & Huang, C. Y. (2019). CHIP attenuates lipopolysaccharide‐induced cardiac hypertrophy and apoptosis by promoting NFATc3 proteasomal degradation. Journal of Cellular Physiology, 234(11), 20128-20138.

Urso, K., Fernández, A., Velasco, P., Cotrina, J., de Andrés, B., Sánchez-Gómez, P., ... & Cano, E. (2019). NFATc3 controls tumour growth by regulating proliferation and migration of human astroglioma cells. Scientific Reports, 9(1), 9361.

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For research use only. Not intended for any clinical use.

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