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Mouse Anti-NCKIPSD Recombinant Antibody (CBWJN-0309) (CBMAB-N0169-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0309
Antibody Isotype
IgG1
Application
WB, Dot

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NCK interacting protein with SH3 domain
Introduction
The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Entrez Gene ID
51517
UniProt ID
Q9NZQ3
Alternative Names
NCK Interacting Protein With SH3 Domain; Wiskott-Aldrich Syndrome Protein-Interacting Protein; SH3 Protein Interacting With Nck, 90 KDa; 90 KDa SH3 Protein Interacting With Nck; Diaphanous Protein Interacting Protein; 54 KDa Vimentin-Interacting Protein; WASP-Interacting SH3-Domain Protein; 54 KDa VacA-Interacting Protein; SH3 Adapter Protein SPIN90; Dia-Interacting Protein 1; Dia Interacting Protein; AF3P21;
Function
Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity).

In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity).

May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis.
Biological Process
Cytoskeleton organization Source: UniProtKB
Endocytosis Source: GO_Central
Positive regulation of neuron projection development Source: Ensembl
Cellular Location
Nucleus
Note: Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.
PTM
A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation t(3;11)(p21;q23) with KMT2A/MLL1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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