Mouse Anti-MYO18B Recombinant Antibody (CBFYM-2981) (CBMAB-M3176-FY)

Name: Mouse Anti-MYO18B Recombinant Antibody (CBFYM-2981)
SKU: CBMAB-M3176-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-2981

Antibody Isotype

IgG2b, k

Application

WB, ELISA

Basic Information

Immunogen

Recombinant protein from human MYO18B

Specificity

Human

Antibody Isotype

IgG2b, k

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Myosin XVIIIB

Introduction

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.

Entrez Gene ID

84700

UniProt ID

Q8IUG5

Alternative Names

Myosin XVIIIB; Unconventional Myosin-XVIIIb; Myosin 18B; KFS4

Function

May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.

Biological Process

Cardiac muscle cell development Source: Ensembl
In utero embryonic development Source: Ensembl
Vasculogenesis Source: Ensembl

Cellular Location

Nucleus
Cytoplasm
Other locations
sarcomere
Note: Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.

Involvement in disease

Klippel-Feil syndrome 4, autosomal recessive, with nemaline myopathy and facial dysmorphism (KFS4):
A form of Klippel-Feil syndrome, a skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. KFS4 features additionally include myopathy, mild short stature, microcephaly, and distinctive facies.

More Infomation

References

Altuame, F. D., Haldeman‐Englert, C., Cupler, E., Al Muhaizea, M. A., Al‐Zaidan, H. I., Hashem, M., & Alkuraya, F. S. (2021). Further delineation of MYO18B‐related autosomal recessive Klippel‐Feil syndrome with myopathy and facial dysmorphism. American Journal of Medical Genetics Part A, 185(2), 370-376.

Brunet, T., Westphal, D. S., Weber, S., Juenger, H., Vlaho, S., Hoefele, J., ... & Wagner, M. (2020). A novel pathogenic variant in MYO18B associating early-onset muscular hypotonia, and characteristic dysmorphic features, delineation of the phenotypic spectrum of MYO18B-related conditions. Gene, 742, 144542.

Jinesh, G. G., Napoli, M., Ackerman, H. D., Raulji, P. M., Montey, N., Flores, E. R., & Brohl, A. S. (2020). Regulation of MYO18B mRNA by a network of C19MC miRNA-520G, IFN-γ, CEBPB, p53 and bFGF in hepatocellular carcinoma. Scientific Reports, 10(1), 12371.

Tang, X., Wang, J., Zhou, S., Zhou, J., Jia, G., Wang, H., ... & Zhang, J. (2019). miR‑760 regulates skeletal muscle proliferation in rheumatoid arthritis by targeting Myo18b. Molecular Medicine Reports, 20(6), 4843-4854.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-MYO18B Recombinant Antibody

Mouse Anti-MYO18B Recombinant Antibody (CBFYM-2980)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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