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Mouse Anti-MYH8 Recombinant Antibody (CBFYM-2941) (CBMAB-M3136-FY)


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Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBFYM-2941
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Myosin Heavy Chain 8, Skeletal Muscle, Perinatal
Specificity
Rat
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MYOSIN HEAVY CHAIN 8
Introduction
This gene encodes a myosin heavy chain. The encoded protein forms a hexamer with two heavy chains, two alkali light chains, and two regulatory light chain components.
Entrez Gene ID
252942
UniProt ID
P04462
Alternative Names
MHCp; Myhsp; Myhs-p; MyHC-pn; AI327267; 4832426G23Rik
Function
Muscle contraction.
Biological Process
ATP metabolic process Source: BHF-UCL
Muscle contraction Source: UniProtKB
Muscle filament sliding Source: BHF-UCL
Skeletal muscle contraction Source: BHF-UCL
Cellular Location
Myofibril
Note: Thick filaments of the myofibrils.
Involvement in disease
Carney complex variant (CACOV):
Carney complex is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas. Familial cardiac myxomas are associated with spotty pigmentation of the skin and other phenotypes, including primary pigmented nodular adrenocortical dysplasia, extracardiac (frequently cutaneous) myxomas, schwannomas, and pituitary, thyroid, testicular, bone, ovarian, and breast tumors. Cardiac myxomas do not develop in all patients with the Carney complex, but affected patients have at least two features of the complex or one feature and a clinically significant family history.
Arthrogryposis, distal, 7 (DA7):
A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA7 is characterized by an inability to open the mouth fully (trismus) and pseudocamptodactyly in which wrist dorsiflexion, but not volarflexion, produces involuntary flexion contracture of distal and proximal interphalangeal joints. Additional features include shortened hamstring muscles and short stature.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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