Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-MVP Recombinant Antibody (2H3-1A6) (CBMAB-A5700-LY)


See all MVP antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
2H3-1A6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MVP (AAH15623, 1 a.a. ~ 893 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Major Vault Protein
Introduction
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. [provided by RefSeq]
Entrez Gene ID
9961
UniProt ID
Q14764
Alternative Names
LRP; VAULT1
Function
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Biological Process
ERBB signaling pathway Source: UniProtKB
mRNA transport Source: UniProtKB-KW
Negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
Negative regulation of protein autophosphorylation Source: UniProtKB
Negative regulation of protein tyrosine kinase activity Source: UniProtKB
Protein transport Source: UniProtKB-KW
Cellular Location
Nucleus
nuclear pore complex
Cytoplasm
Other locations
perinuclear region
Note: 5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).
PTM
Phosphorylated on Tyr residues after EGF stimulation.
Dephosphorylated by PTPN11.
More Infomation

Wang, R., Yang, Y., Zhang, Z., Zhao, N., Wiemer, E. A., Ben, J., ... & Yuan, L. (2023). Major vault protein (MVP) suppresses aging-and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts. Cell Death & Disease, 14(9), 604.

Liu, Q., Pan, J., Bao, L., Xu, C., Qi, Y., Jiang, B., ... & Chen, Q. (2022). Major vault protein prevents atherosclerotic plaque destabilization by suppressing macrophage ASK1-JNK signaling. Arteriosclerosis, Thrombosis, and Vascular Biology, 42(5), 580-596.

Yuan, L., Zhao, N., Wang, J., Liu, Y., Meng, L., Guo, S., ... & Ma, J. (2021). Major vault protein (MVP) negatively regulates osteoclastogenesis via calcineurin-NFATc1 pathway inhibition. Theranostics, 11(15), 7247.

Ramberg, H., Richardsen, E., de Souza, G. A., Rakaee, M., Stensland, M. E., Braadland, P. R., ... & Andersen, S. (2021). Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer. Carcinogenesis, 42(5), 685-693.

Wang, W., Xiong, L., Wang, P., Wang, F., & Ma, Q. (2020). Major vault protein plays important roles in viral infection. IUBMB life, 72(4), 624-631.

Grossi, S., Fenini, G., Kockmann, T., Hennig, P., Di Filippo, M., & Beer, H. D. (2020). Inactivation of the cytoprotective major vault protein by caspase-1 and-9 in epithelial cells during apoptosis. Journal of Investigative Dermatology, 140(7), 1335-1345.

Yu, H., Li, M., He, R., Fang, P., Wang, Q., Yi, Y., ... & Liu, S. (2020). Major vault protein promotes hepatocellular carcinoma through targeting interferon regulatory factor 2 and decreasing p53 activity. Hepatology, 72(2), 518-534.

Ben, J., Jiang, B., Wang, D., Liu, Q., Zhang, Y., Qi, Y., ... & Chen, Q. (2019). Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation. Nature communications, 10(1), 1801.

Lehuédé, C., Li, X., Dauvillier, S., Vaysse, C., Franchet, C., Clement, E., ... & Muller, C. (2019). Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP). Breast Cancer Research, 21, 1-17.

Bai, H., Wang, C., Qi, Y., Xu, J., Li, N., Chen, L., ... & Chen, Q. (2019). Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway. BMC cancer, 19(1), 1-13.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-MVP Recombinant Antibody (2H3-1A6)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry