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Mouse Anti-MRS2 Recombinant Antibody (CBFYH-2656) (CBMAB-H0586-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2656
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MRS2, MAGNESIUM TRANSPORTER
Introduction
MRS2 (MRS2, Magnesium Transporter) is a Protein Coding gene. Diseases associated with MRS2 include Basilar Artery Occlusion. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Miscellaneous transport and binding events. Gene Ontology (GO) annotations related to this gene include magnesium ion transmembrane transporter activity.
Entrez Gene ID
57380
UniProt ID
Q9HD23
Alternative Names
MRS2, Magnesium Transporter; MRS2-Like Protein; MRS2L; HPT; MRS2 Magnesium Homeostasis Factor Homolog (S. Cerevisiae); MRS2-Like, Magnesium Homeostasis Factor (S. Cerevisiae); Magnesium Transporter MRS2 Homolog, Mitochondrial; MRS2-Like, Magnesium Homeostasis Factor; Putative Magnesium Transporter
Function
Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665).

Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).
Biological Process
Magnesium ion transport Source: GO_Central
Mitochondrial magnesium ion transmembrane transport Source: UniProtKB
Transmembrane transport Source: Reactome
Cellular Location
Mitochondrion
Involvement in disease
Mitochondrion inner membrane
Topology
Mitochondrial matrix: 50-339
Helical: 340-360
Mitochondrial intermembrane: 361-372
Helical: 373-393
Mitochondrial matrix: 394-443
More Infomation

Lai, L. T. F., Balaraman, J., Zhou, F., & Matthies, D. (2023). Cryo-EM structures of human magnesium channel MRS2 reveal gating and regulatory mechanisms. Nature Communications, 14(1), 7207.

Liu, W., Khan, S., Tong, M., Hu, H., Yin, L., & Huang, J. (2023). Identification and Expression of the CorA/MRS2/ALR Type Magnesium Transporters in Tomato. Plants, 12(13), 2512.

Uthayabalan, S., Vishnu, N., Madesh, M., & Stathopulos, P. B. (2023). The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity. Life Science Alliance, 6(4).

Joshi, A., & Gohil, V. M. (2023). Cardiolipin deficiency leads to the destabilization of mitochondrial magnesium channel MRS2 in Barth syndrome. Human Molecular Genetics, 32(24), 3353-3360.

Madaris, T. R., Venkatesan, M., Maity, S., Stein, M. C., Vishnu, N., Venkateswaran, M. K., ... & Madesh, M. (2023). Limiting Mrs2-dependent mitochondrial Mg2+ uptake induces metabolic programming in prolonged dietary stress. Cell reports, 42(3).

Li, M., Li, Y., Lu, Y., Li, J., Lu, X., Ren, Y., ... & Shen, Y. (2023). Molecular basis of Mg2+ permeation through the human mitochondrial Mrs2 channel. Nature communications, 14(1), 4713.

Ishijima, S., Shiomi, R., & Sagami, I. (2021). Functional analysis of whether the glycine residue of the GMN motif of the Arabidopsis MRS2/MGT/CorA-type Mg2+ channel protein AtMRS2-11 is critical for Mg2+ transport activity. Archives of Biochemistry and Biophysics, 697, 108673.

Tong, M., Liu, W., He, H., Hu, H., Ding, Y., Li, X., ... & Yin, L. (2020). Identification and functional analysis of the CorA/MGT/MRS2-type magnesium transporter in banana. Plos one, 15(10), e0239058.

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For research use only. Not intended for any clinical use.

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