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Mouse Anti-MRI1 Recombinant Antibody (CBFYM-2548) (CBMAB-M2735-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2548
Antibody Isotype
IgG1
Application
FC, IF, IHC, IHC-P, WB

Basic Information

Immunogen
Protein expressed in 293T cell transfected with human MRI1 expression vector
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Methylthioribose-1-Phosphate Isomerase 1
Introduction
This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease.
Entrez Gene ID
84245
UniProt ID
Q9BV20
Alternative Names
Methylthioribose-1-Phosphate Isomerase 1; Mediator Of RhoA-Dependent Invasion; Translation Initiation Factor EIF-2B Subunit Alpha/Beta/Delta-Like Protein; S-Methyl-5-Thioribose-1-Phosphate Isomerase 1; MTR-1-P Isomerase; EC 5.3.1.23; M1Pi; MRDI
Function
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.
Biological Process
L-methionine salvage from methylthioadenosine Source: GO_Central
L-methionine salvage from S-adenosylmethionine Source: UniProtKB-UniRule
Cellular Location
Nucleus
Cytoplasm
Other locations
Cell projection
Note: Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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