Rabbit Anti-MORF4L1 Recombinant Antibody (D2Y4J) (CBMAB-CP1575-LY)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat, Monkey, Hamster, Chicken, Cattle, Pig

Clone

D2Y4J

Antibody Isotype

IgG

Application

WB, IP

Basic Information

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala237 of human MORF4L1/MRG15 protein.

Specificity

Human, Mouse, Rat, Monkey, Hamster, Chicken, Cattle, Pig

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

MORF4L1

Introduction

MORF4L1 (Mortality Factor 4 Like 1) is a Protein Coding gene. Diseases associated with MORF4L1 include Paraneoplastic Cerebellar Degeneration. Among its related pathways are Chromatin organization and Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include chromatin binding and protein N-terminus binding. An important paralog of this gene is MORF4L2.

Entrez Gene ID

Human	10933
Mouse	21761
Rat	300891
Monkey	711357
Cattle	614390
Hamster	101826650
Chicken	554283
Pig	100154823

UniProt ID

Human	Q9UBU8
Mouse	P60762
Rat	Q6AYU1
Monkey	F6VZK6
Cattle	F1N4R2
Hamster	A0A1U7QWR3
Pig	F1RKS0

Alternative Names

Mortality Factor 4 Like 1; Transcription Factor-Like Protein MRG15; MORF-Related Gene On Chromosome 15; MORF-Related Gene 15 Protein; Protein MSL3-1; MRG15; Esa1p-Associated Factor 3 Homolog (S. Cerevisiae); Esa1p-Associated Factor 3 Homolog;

Function

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.

Biological Process

Cell population proliferation Source: Ensembl
Chromatin organization Source: UniProtKB-KW
Double-strand break repair via homologous recombination Source: UniProtKB
Histone acetylation Source: GO_Central
Histone deacetylation Source: UniProtKB
Histone H2A acetylation Source: UniProtKB
Histone H4 acetylation Source: UniProtKB
Positive regulation of double-strand break repair via homologous recombination Source: ComplexPortal
Positive regulation of transcription, DNA-templated Source: ComplexPortal
Regulation of apoptotic process Source: ComplexPortal
Regulation of cell cycle Source: ComplexPortal
Regulation of double-strand break repair Source: ComplexPortal
Regulation of growth Source: UniProtKB-KW

Cellular Location

Nucleus

More Infomation

References

Xin, Y., Chen, X., Zhang, M., Jin, Y., Xu, J., Zhang, J., ... & Xu, P. (2023). Ubiquitin-Mediated Degradation of MORF4L1 By FBXO11 Suppresses Cholesterol Biosynthesis in T Cell Acute Lymphoblastic Leukemia. Blood, 142, 4148.

Zhao, H., Chen, W., Chen, J., Qi, C., Wang, T., Zhang, J., ... & Zhang, Y. (2022). ADSCs promote tenocyte proliferation by reducing the methylation level of lncRNA morf4l1 in tendon injury. Frontiers in Chemistry, 10, 908312.

Porras-Yakushi, T. R., Reitsma, J. M., Sweredoski, M. J., Deshaies, R. J., & Hess, S. (2021). In-depth proteomic analysis of proteasome inhibitors bortezomib, carfilzomib and MG132 reveals that mortality factor 4-like 1 (MORF4L1) protein ubiquitylation is negatively impacted. Journal of proteomics, 241, 104197.

Kalofonou, F., Leach, D., Hamilton, M., Mcguire, S. E., Fletcher, C., Waxman, J., & Bevan, C. L. (2019). MiR-1271-5p: An AR-modulatory microRNA with a distinct role in prostate cancer progression, through SND1 and MORF4L1 interaction.

Sang, Y., Zhang, R., Sun, L., Chen, K. K., Li, S. W., Xiong, L., ... & Huang, G. (2019). MORF4L1 suppresses cell proliferation, migration and invasion by increasing p21 and E‑cadherin expression in nasopharyngeal carcinoma. Oncology letters, 17(1), 294-302.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-MORF4L1 (AA 1-100) Recombinant Antibody (CBFYM-2476)

Mouse Anti-MORF4L1 (AA 6-77) Recombinant Antibody (CBFYM-2475)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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