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Mouse Anti-MOCS3 (AA 1-461) Recombinant Antibody (CBFYM-0487) (CBMAB-M0615-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0487
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-461

Target

Full Name
Molybdenum Cofactor Synthesis 3
Introduction
Molybdenum cofactor is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14.
Entrez Gene ID
27304
UniProt ID
O95396
Alternative Names
Molybdenum Cofactor Synthesis 3; Ubiquitin-Like Modifier Activating Enzyme 4; Molybdenum Cofactor Synthesis Protein 3; Molybdopterin Synthase Sulfurylase; MPT Synthase Sulfurylase; UBA4; UBA4, Ubiquitin-Activating Enzyme E1 Homolog (Yeast); Adenylyltransferase And Sulfurtransferase MOCS3; UBA4, Ubiquitin-Activating Enzyme E1 Homolog
Function
Plays a central role in 2-thiolation of mcm5S2U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
Biological Process
Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB
Protein urmylation Source: GO_Central
tRNA thio-modification Source: UniProtKB
tRNA wobble position uridine thiolation Source: GO_Central
tRNA wobble uridine modification Source: UniProtKB
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

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