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Mouse Anti-MLX Antibody (1G8) (CBMAB-0680-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1G8
Antibody Isotype
IgG2b
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MLX
Introduction
MLX (MAX-like protein X) belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. MLX may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4.
Entrez Gene ID
6945
UniProt ID
Q9UH92
Alternative Names
bHLHd13; MAD7; MXD7; TCFL4
Function
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
Biological Process
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Isoform Alpha:
Cytoplasm
Note: Found predominantly in the cytoplasm (PubMed:10918583).
Isoform Beta:
Cytoplasm
Note: Found predominantly in the cytoplasm (PubMed:10918583).
Isoform Gamma:
Nucleus
Note: Found predominantly in the nucleus (PubMed:10918583).
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For research use only. Not intended for any clinical use.

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