Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-MINPP1 Recombinant Antibody (CBFYM-2230) (CBMAB-M2413-FY)


See all MINPP1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2230
Antibody Isotype
IgG1
Application
IF

Basic Information

Immunogen
Full length human recombinant protein of human MINPP1(NP_004888) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MULTIPLE INOSITOL-POLYPHOSPHATE PHOSPHATASE 1
Introduction
This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase in the Rapoport-Luebering shunt of the glycolytic pathway.
Entrez Gene ID
9562
UniProt ID
Q9UNW1
Alternative Names
Multiple Inositol-Polyphosphate Phosphatase 1; Multiple Inositol Polyphosphate Histidine Phosphatase, 1; Inositol (1,3,4,5)-Tetrakisphosphate 3-Phosphatase; 2,3-Bisphosphoglycerate 3-Phosphatase; Ins(1,3,4,5)P(4) 3-Phosphatase; 2,3-BPG Phosphatase; EC 3.1.3.62
Function
Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity).
Biological Process
Bone mineralization Source: UniProtKB
Inositol phosphate metabolic process Source: Reactome
Ossification Source: UniProtKB
Polyphosphate metabolic process Source: ProtInc
Cellular Location
Endoplasmic reticulum lumen
Involvement in disease
Thyroid cancer, non-medullary, 2 (NMTC2):
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
More Infomation

Ullah, A., Shah, A. A., Alluqmani, M., Haider, N., Aman, H., Alfadhli, F., ... & Basit, S. (2022). Clinical and genetic characterization of patients segregating variants in KPTN, MINPP1, NGLY1, AP4B1, and SON underlying neurodevelopmental disorders: Genetic and phenotypic expansion. International Journal of Developmental Neuroscience, 82(8), 788-804.

Nguyen Trung, M., Kieninger, S., Fandi, Z., Qiu, D., Liu, G., Mehendale, N. K., ... & Fiedler, D. (2022). Stable isotopomers of myo-inositol uncover a complex MINPP1-dependent inositol phosphate network. ACS Central Science, 8(12), 1683-1694.

Zubair, M., Hamzah, R., Griffin, R., & Ali, N. (2022). Identification and functional characterization of multiple inositol polyphosphate phosphatase1 (Minpp1) isoform-2 in exosomes with potential to modulate tumor microenvironment. Plos one, 17(3), e0264451.

Appelhof, B., Wagner, M., Hoefele, J., Heinze, A., Roser, T., Koch-Hogrebe, M., ... & Jamra, R. A. (2021). Pontocerebellar hypoplasia due to bi-allelic variants in MINPP1. European Journal of Human Genetics, 29(3), 411-421.

Chen, W., Jiang, J., Gong, L., Shu, Z., Xiang, D., Zhang, X., ... & Diao, H. (2021). Hepatitis B virus P protein initiates glycolytic bypass in HBV-related hepatocellular carcinoma via a FOXO3/miRNA-30b-5p/MINPP1 axis. Journal of Experimental & Clinical Cancer Research, 40, 1-18.

Ucuncu, E., Rajamani, K., Wilson, M. S., Medina-Cano, D., Altin, N., David, P., ... & Cantagrel, V. (2020). MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. Nature communications, 11(1), 6087.

Ucuncu, E., Rajamani, K., Wilson, M. S., Medina-Cano, D., Altin, N., David, P., ... & Cantagrel, V. (2020). MINPP1 prevents intracellular accumulation of the cation chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. bioRxiv, 2020-05.

Shi, L., Liu, L., Lv, X., Ma, Z., Yang, Y., Li, Y., ... & Han, B. (2019). Polymorphisms and genetic effects of PRLR, MOGAT1, MINPP1 and CHUK genes on milk fatty acid traits in Chinese Holstein. BMC genetics, 20(1), 1-8.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-MINPP1 Recombinant Antibody (CBFYM-2230)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry