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Mouse Anti-MICB Recombinant Antibody (CBFYM-2215) (CBMAB-M2398-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2215
Antibody Isotype
IgG2
Application
FC, IHC, Neut, WB

Basic Information

Immunogen
Recombinant protein corresponding to human MICB
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE B
Introduction
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
4277
UniProt ID
Q29980
Alternative Names
MHC Class I Polypeptide-Related Sequence B; PERB11.2; MHC Class I-Like Molecule PERB11.2-IMX; MHC Class I Chain-Related Protein B; Stress Inducible Class I Homolog; MHC Class I Mic-B Antigen; MIC-B
Function
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Gamma-delta T cell activation Source: UniProtKB
Immune response-activating cell surface receptor signaling pathway Source: UniProtKB
Negative regulation of defense response to virus by host Source: UniProtKB
Response to heat Source: UniProtKB
Response to oxidative stress Source: UniProtKB
Response to retinoic acid Source: UniProtKB
Cellular Location
Plasma membrane
Cell membrane
Note: Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.
Involvement in disease
Rheumatoid arthritis (RA):
An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Topology
Extracellular: 23-309
Helical: 310-330
Cytoplasmic: 331-383
PTM
Proteolytically cleaved and released from the cell surface of tumor cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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