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Mouse Anti-MGST2 (AA 1-147) Recombinant Antibody (CBFYM-2193) (CBMAB-M2375-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2193
Antibody Isotype
IgG2b, k
Application
ELISA, IP

Basic Information

Immunogen
Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MAGNSILLAA VSILSACQQS YFALQVGKAR LKYKVTPPAV TGSPEFERVF RAQQNCVEFY PIFIITLWMA GWYFNQVFAT CLGLVYIYGR HLYFWGYSEA AKKRITGFRL SLGILALLTL LGALGIANSF LDEYLDLNIA K
Specificity
Human
Antibody Isotype
IgG2b, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-147

Target

Full Name
microsomal glutathione S-transferase 2
Introduction
The MAPEG family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Entrez Gene ID
4258
UniProt ID
Q99735
Alternative Names
Microsomal Glutathione S-Transferase 2; Microsomal GST-II; Microsomal GST-2; GST2; EC 2.5.1.18; MGST-II
Function
Catalyzes several different glutathione-dependent reactions (PubMed:8703034, PubMed:9278457, PubMed:23409838, PubMed:26656251, PubMed:26066610).

Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed:9278457, PubMed:23409838).

Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed:23409838, PubMed:8703034).

Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed:23409838, PubMed:26656251).

Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251).
Biological Process
Glutathione biosynthetic process Source: UniProtKB
Leukotriene biosynthetic process Source: UniProtKB
Lipid metabolic process Source: BHF-UCL
Membrane lipid catabolic process Source: BHF-UCL
Positive regulation of inflammatory response Source: BHF-UCL
Cellular Location
Endoplasmic reticulum
Endoplasmic reticulum membrane
Microsome membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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