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Mouse Anti-MGAT4B Recombinant Antibody (1F4) (CBMAB-A5452-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1F4
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
MGAT4B (NP_055090, 401 a.a. ~ 500 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
Introduction
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq]
Entrez Gene ID
11282
UniProt ID
Q9UQ53
Alternative Names
GNT-IV; GNT-IVB
Function
Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (PubMed:17006639, PubMed:10372966).

Prefers complex-type N-glycans over hybrid-types (PubMed:17006639).

Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis (PubMed:17006639).
Biological Process
N-glycan processing Source: ProtInc
Positive regulation of protein glycosylation in Golgi Source: UniProtKB
Protein N-linked glycosylation Source: GO_Central
Viral protein processing Source: Reactome
Cellular Location
Golgi apparatus
Golgi apparatus membrane
Note: A processed soluble form also exists.
Topology
Cytoplasmic: 1-7
Helical: 8-28
Lumenal: 29-548
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

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