Mouse Anti-MFSD1 Recombinant Antibody (CBFYM-2161) (CBMAB-M2343-FY)

Name: Mouse Anti-MFSD1 Recombinant Antibody (CBFYM-2161)
SKU: CBMAB-M2343-FY
Rating: 5 (1 reviews)

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Summary

Host Animal

Mouse

Specificity

Mouse, Rat, Human

Clone

CBFYM-2161

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Mouse, Rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MAJOR FACILITATOR SUPERFAMILY DOMAIN CONTAINING 1

Introduction

MFSD1 is a Protein Coding gene. Diseases associated with MFSD1 include Pleomorphic Adenoma Carcinoma and Gastrointestinal System Benign Neoplasm.

Entrez Gene ID

Human	64747
Mouse	66868
Rat	361957

UniProt ID

Human	Q9H3U5
Mouse	Q9DC37
Rat	D3ZV75

Alternative Names

Major Facilitator Superfamily Domain Containing 1; Smooth Muscle Cell-Associated Protein 4; SMAP4; Major Facilitator Superfamily Domain-Containing Protein 1; SMAP-4

Function

Lysosomal transporter which is essential for liver homeostasis. Required to maintain stability and lysosomal localization of GLMP.

Biological Process

Protein localization to lysosome Source: UniProtKB
Protein stabilization Source: UniProtKB

Cellular Location

Lysosome membrane

PTM

Not N-glycosylated.

More Infomation

References

Zhong, X., Moresco, J. J., Diedrich, J. K., Pinto, A. M., SoRelle, J. A., Wang, J., ... & Choi, J. H. (2023). Essential role of MFSD1-GLMP-GIMAP5 in lymphocyte survival and liver homeostasis. Proceedings of the National Academy of Sciences, 120(50), e2314429120.

Jungnickel, K. E. J., Guelle, O., Iguchi, M., Dong, W., Kotov, V., Gabriel, F., ... & Damme, M. (2023). MFSD1 in complex with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes. bioRxiv, 2023-12.

Roblek, M., Bicher, J., van Gogh, M., György, A., Seeböck, R., Szulc, B., ... & Siekhaus, D. E. (2022). The Solute Carrier MFSD1 Decreases the Activation Status of β1 Integrin and Thus Tumor Metastasis. Frontiers in oncology, 12, 777634.

López, D. M., Kählau, L., Jungnickel, K. E. J., Löw, C., & Damme, M. (2020). Characterization of the complex of the lysosomal membrane transporter MFSD1 and its accessory subunit GLMP. The FASEB Journal, 34(11), 14695-14709.

Massa López, D., Thelen, M., Stahl, F., Thiel, C., Linhorst, A., Sylvester, M., ... & Damme, M. (2019). The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP. Elife, 8, e50025.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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