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Mouse Anti-MEIS2 (AA 1-382) Recombinant Antibody (CBFYM-0503) (CBMAB-M0631-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0503
Antibody Isotype
IgG1
Application
ELISA, ICC, IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-382

Target

Full Name
MEIS2
Introduction
This gene encodes a homeobox protein belonging to the TALE family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.
Entrez Gene ID
4212
UniProt ID
O14770
Alternative Names
Meis Homeobox 2; Meis1-Related Protein 1; MRG1; Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 2 (Mouse); Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 2; TALE Homeobox Protein Meis2; Meis (Mouse) Homolog 2
Function
Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.
Biological Process
Animal organ morphogenesis Source: GO_Central
Brain development Source: GO_Central
Embryonic pattern specification Source: GO_Central
Eye development Source: GO_Central
Negative regulation of myeloid cell differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: ProtInc
Pancreas development Source: Ensembl
Positive regulation of cardiac muscle myoblast proliferation Source: BHF-UCL
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of mitotic cell cycle Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to growth factor Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Visual learning Source: Ensembl
Cellular Location
Nucleus
Other locations
perinuclear region
Involvement in disease
Cleft palate, cardiac defects, and mental retardation (CPCMR):
An autosomal dominant disease characterized by multiple congenital malformations, mild-to-severe intellectual disability with poor speech, and delayed psychomotor development. Congenital malformations include heart defects, cleft lip/palate, distally-placed thumbs and toes, and cutaneous syndactyly between the second and third toes.
More Infomation

Roussel, J., Larcher, R., Sicard, P., Bideaux, P., Richard, S., Marmigère, F., & Thireau, J. (2022). The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice. Scientific Reports, 12(1), 20150.

De Wyn, J., Zimmerman, M. W., Weichert-Leahey, N., Nunes, C., Cheung, B. B., Abraham, B. J., ... & Durinck, K. (2021). MEIS2 is an adrenergic core regulatory transcription factor involved in early initiation of TH-MYCN-driven neuroblastoma formation. Cancers, 13(19), 4783.

Durán Alonso, M. B., Vendrell, V., López-Hernández, I., Alonso, M. T., Martin, D. M., Giráldez, F., ... & Schimmang, T. (2021). Meis2 is required for inner ear formation and proper morphogenesis of the cochlea. Frontiers in Cell and Developmental Biology, 9, 679325.

Giliberti, A., Currò, A., Papa, F. T., Frullanti, E., Ariani, F., Coriolani, G., ... & Mari, F. (2020). MEIS2 gene is responsible for intellectual disability, cardiac defects and a distinct facial phenotype. European Journal of Medical Genetics, 63(1), 103627.

Wang, L., Tang, Q., Xu, J., Li, H., Yang, T., Li, L., ... & Chen, Y. (2020). The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice. Journal of Biological Chemistry, 295(16), 5449-5460.

Alam, P., Haile, B., Arif, M., Pandey, R., Rokvic, M., Nieman, M., ... & Kanisicak, O. (2019). Inhibition of senescence‐associated genes Rb1 and Meis2 in adult cardiomyocytes results in cell cycle reentry and cardiac repair post–myocardial infarction. Journal of the American Heart Association, 8(15), e012089.

Wang, X., Ghareeb, W. M., Zhang, Y., Yu, Q., Lu, X., Huang, Y., ... & Chi, P. (2019). Hypermethylated and downregulated MEIS2 are involved in stemness properties and oxaliplatin‐based chemotherapy resistance of colorectal cancer. Journal of Cellular Physiology, 234(10), 18180-18191.

Wan, Z., Chai, R., Yuan, H., Chen, B., Dong, Q., Zheng, B., ... & Hu, X. (2019). MEIS2 promotes cell migration and invasion in colorectal cancer. Oncology reports, 42(1), 213-223.

Nørgaard, M., Haldrup, C., Bjerre, M. T., Høyer, S., Ulhøi, B., Borre, M., & Sørensen, K. D. (2019). Epigenetic silencing of MEIS2 in prostate cancer recurrence. Clinical epigenetics, 11, 1-14.

Verheije, R., Kupchik, G. S., Isidor, B., Kroes, H. Y., Lynch, S. A., Hawkes, L., ... & Breckpot, J. (2019). Heterozygous loss-of-function variants of MEIS2 cause a triad of palatal defects, congenital heart defects, and intellectual disability. European Journal of Human Genetics, 27(2), 278-290.

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For research use only. Not intended for any clinical use.

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