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Mouse Anti-MATK Recombinant Antibody (CBFYM-1760) (CBMAB-M1928-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1760
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Megakaryocyte-Associated Tyrosine Kinase
Introduction
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.
Entrez Gene ID
4145
UniProt ID
P42679
Alternative Names
Megakaryocyte-Associated Tyrosine Kinase; Hematopoietic Consensus Tyrosine-Lacking Kinase; Tyrosine-Protein Kinase CTK; Protein Kinase HYL; Leukocyte Carboxyl-Terminal Src Kinase Related; Csk-Type Protein Tyrosine Kinase; Hydroxyaryl-Protein Kinase; Tyrosylprotein Kinase; Csk-Homologous Kinase; CSK Homologous Kinase; Tyrosine Kinase MATK
Function
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
Biological Process
Positive regulation of cell population proliferation Source: ProtInc
Protein phosphorylation Source: ProtInc
Cellular Location
Cytoplasm and Cytosol
Other locations
Membrane
Note: In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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