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Mouse Anti-MARCH9 Recombinant Antibody (CBFYM-0580) (CBMAB-M0709-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0580
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
membrane-associated ring finger (C3HC4) 9
Introduction
MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases. MARCH enzymes add ubiquitin to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment.
Entrez Gene ID
92979
UniProt ID
Q86YJ5
Alternative Names
Membrane Associated Ring-CH-Type Finger 9; Membrane-Associated Ring Finger (C3HC4) 9; Membrane-Associated RING Finger Protein 9; RING-Type E3 Ubiquitin Transferase MARCH9; Membrane-Associated RING-CH Protein IX; RING Finger Protein 179
Function
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Biological Process
Protein ubiquitination Source: UniProtKB-UniPathway
Cellular Location
Lysosome
Lysosome membrane
Golgi apparatus
Golgi apparatus membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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