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Mouse Anti-MAOA (AA 249-484 ) Recombinant Antibody (CBFYM-1371) (CBMAB-M1530-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1371
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 249-484 of human MAOA produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 249-484

Target

Full Name
MONOAMINE OXIDASE A
Introduction
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
Entrez Gene ID
4128
UniProt ID
P21397
Alternative Names
Monoamine Oxidase A; Monoamine Oxidase Type A; EC 1.4.3.4; MAO-A; Amine Oxidase [Flavin-Containing] A; EC 1.4.3; BRNRS
Function
Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:20493079, PubMed:8316221, PubMed:18391214, PubMed:24169519).
Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519).
Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity).
Biological Process
Cellular biogenic amine metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Dopamine catabolic processManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Neurotransmitter catabolic processIEA:UniProtKB-KW
Positive regulation of signal transductionIEA:Ensembl
Cellular Location
Mitochondrion outer membrane
Involvement in disease
Brunner syndrome (BRNRS):
A form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.
Topology
Cytoplasmic: 1-497
Helical: 498-518
Lumenal: 519-527
More Infomation

Han, H., Li, H., Ma, Y., Zhao, Z., An, Q., Zhao, J., & Shi, C. (2023). Monoamine oxidase A (MAOA): A promising target for prostate cancer therapy. Cancer Letters, 216188.

Pueyo, N., Navarro, J. B., Fatjó-Vilas, M., de la Osa, N., Penelo, E., Fañanás, L., & Ezpeleta, L. (2021). Monoamine oxidase A (MAOA) interaction with parenting practices on callous-unemotional traits in preschoolers. The European Journal of Psychiatry, 35(4), 225-233.

Wang, X., Li, B., Kim, Y. J., Wang, Y. C., Li, Z., Yu, J., ... & Yang, L. (2021). Targeting monoamine oxidase A for T cell–based cancer immunotherapy. Science immunology, 6(59), eabh2383.

Peters, T. M., Lammerts van Bueren, I., Geurtz, B. P., Coene, K. L., de Leeuw, N., Brunner, H. G., ... & Verbeek, M. M. (2021). Monoamine oxidase A activity in fibroblasts as a functional confirmation of MAOA variants. JIMD reports, 58(1), 114-121.

Schiele, M. A., Thiel, C., Deckert, J., Zaudig, M., Berberich, G., & Domschke, K. (2020). Monoamine oxidase A hypomethylation in obsessive-compulsive disorder: reversibility by successful psychotherapy?. International Journal of Neuropsychopharmacology, 23(5), 319-323.

Checknita, D., Bendre, M., Ekström, T. J., Comasco, E., Tiihonen, J., Hodgins, S., & Nilsson, K. W. (2020). Monoamine oxidase A genotype and methylation moderate the association of maltreatment and aggressive behaviour. Behavioural brain research, 382, 112476.

Kolla, N. J., & Bortolato, M. (2020). The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men. Progress in neurobiology, 194, 101875.

Gaur, S., Gross, M. E., Liao, C. P., Qian, B., & Shih, J. C. (2019). Effect of Monoamine oxidase A (MAOA) inhibitors on androgen‐sensitive and castration‐resistant prostate cancer cells. The Prostate, 79(6), 667-677.

Byrd, A. L., Manuck, S. B., Hawes, S. W., Vebares, T. J., Nimgaonkar, V., Chowdari, K. V., ... & Stepp, S. D. (2019). The interaction between monoamine oxidase A (MAOA) and childhood maltreatment as a predictor of personality pathology in females: Emotional reactivity as a potential mediating mechanism. Development and psychopathology, 31(1), 361-377.

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For research use only. Not intended for any clinical use.

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