Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-MAFK (AA 1-156) Recombinant Antibody (CBFYM-0115) (CBMAB-M0133-FY)


See all MAFK antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0115
Antibody Isotype
IgG2a, k
Application
WB, ELISA

Basic Information

Immunogen
Recombinant human MAFK (1-156aa) purified from E. coli
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-156

Target

Full Name
MAF BZIP TRANSCRIPTION FACTOR K
Introduction
The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions. LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2. NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase and ferrochelatase. NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein, or MafK) and p45. Both subunits are members of the activator protein-1 superfamily of basic leucine zipper proteins. Maf homodimers suppress transcription at NFE2 sites.
Entrez Gene ID
7975
UniProt ID
O60675
Alternative Names
MAF BZIP Transcription Factor K; Erythroid Transcription Factor NF-E2 P18 Subunit; V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog K; Basic-Leucine Zipper Transcription Factor MafK; Nuclear Factor Erythroid-2, Ubiquitous (P18); V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Family, Protein K
Function
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:9150357).
However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9150357, PubMed:8932385).
Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (PubMed:9150357).
Biological Process
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-MAFK (AA 1-156) Recombinant Antibody (CBFYM-0115)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry