Mouse Anti-LYPD3 Recombinant Antibody (3G10) (CBMAB-A5138-LY)

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Summary

Host Animal

Mouse

Specificity

Human

Clone

3G10

Antibody Isotype

IgG2a, κ

Application

WB, ELISA

Basic Information

Immunogen

LYPD3 (NP_055215.2, 1 a.a. ~ 346 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

LY6/PLAUR domain containing 3

Entrez Gene ID

27076

UniProt ID

O95274

Alternative Names

C4.4A

Function

Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.

Biological Process

Cell-matrix adhesionIEA:Ensembl
Negative regulation of smooth muscle cell apoptotic processManual Assertion Based On ExperimentIGI:ARUK-UCL

Cellular Location

Cell membrane

PTM

N-glycosylated and O-glycosylated.

More Infomation

References

Hu, Y. D., Wu, K., Liu, Y. J., Zhang, Q., Shen, H., Ji, J., ... & Xi, S. Y. (2023). LY6/PLAUR domain containing 3 (LYPD3) maintains melanoma cell stemness and mediates an immunosuppressive microenvironment. Biology Direct, 18(1), 72.

Hu, T., Zhang, Y., Yang, T., He, Q., & Zhao, M. (2022). LYPD3, a New Biomarker and Therapeutic Target for Acute Myelogenous Leukemia. Frontiers in Genetics, 13, 795820.

Kehler, P., Neumann, T., Jaekel, A., Gellert, J., Danielczyk, A., Weiß, L., ... & Weiske, M. (2022). 1347 Targeting of a cancer-associated LYPD3 glycoform for tumor therapy.

Hu, P., Huang, Y., Gao, Y., Yan, H., Li, X., Zhang, J., ... & Zhao, Y. (2020). Elevated expression of LYPD3 is associated with lung adenocarcinoma carcinogenesis and poor prognosis. DNA and Cell Biology, 39(4), 522-532.

Yue, J., Zhu, T., Yang, J., Si, Y., Xu, X., Fang, Y., & Fu, W. (2020). CircCBFB-mediated miR-28-5p facilitates abdominal aortic aneurysm via LYPD3 and GRIA4. Life sciences, 253, 117533.

Gruet, M., Cotton, D., Coveney, C., Boocock, D. J., Wagner, S., Komorowski, L., ... & Powe, D. G. (2020). β2-adrenergic signalling promotes cell migration by upregulating expression of the metastasis-associated molecule LYPD3. Biology, 9(2), 39.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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