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Mouse Anti-LPCAT1 Recombinant Antibody (CBYJL-1916) (CBMAB-L1950-YJ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYJL-1916
Antibody Isotype
IgG2b
Application
ELISA, WB, IHC, IF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LPCAT1
Introduction
LPCAT1 is a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. LPCAT1 plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers.
Entrez Gene ID
Human79888
Mouse210992
Rat361467
UniProt ID
HumanQ8NF37
MouseQ3TFD2
RatQ1HAQ0
Alternative Names
AYTL2; lpcat; AGPAT9; PFAAP3; AGPAT10; LPCAT-1; lysoPAFAT
Function
Exhibits acyltransferase activity (PubMed:21498505, PubMed:18156367).
Exhibits acetyltransferase activity (By similarity).
Activity is calcium-independent (By similarity).
Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505, PubMed:18156367).
Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity).
Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity).
Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity).
May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity).
Involved in the regulation of lipid droplet number and size (PubMed:25491198).
Biological Process
Negative regulation of phosphatidylcholine biosynthetic processIEA:Ensembl
Phosphatidic acid biosynthetic processTAS:Reactome
Phosphatidylcholine acyl-chain remodelingManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylglycerol acyl-chain remodelingTAS:Reactome
Phospholipid biosynthetic processISS:UniProtKB
Positive regulation of protein catabolic processIEA:Ensembl
Retina development in camera-type eyeIEA:Ensembl
Surfactant homeostasisIEA:Ensembl
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane
Cell membrane
Lipid droplet
May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm.
Topology
Cytoplasmic: 1-57
Helical: 58-78
Lumenal: 79-534
More Infomation

Huang, Y., Wang, Y., Wang, Y., Wang, N., Duan, Q., Wang, S., ... & Zheng, Y. (2022). LPCAT1 promotes cutaneous squamous cell carcinoma via EGFR-mediated protein kinase B/p38MAPK signaling pathways. Journal of Investigative Dermatology, 142(2), 303-313.

Ding, J., Ding, X., & Leng, Z. (2022). LPCAT1 promotes gefitinib resistance via upregulation of the EGFR/PI3K/AKT signaling pathway in lung adenocarcinoma. Journal of Cancer, 13(6), 1837.

He, R. Q., Li, J. D., Du, X. F., Dang, Y. W., Yang, L. J., Huang, Z. G., ... & Chen, G. (2021). LPCAT1 overexpression promotes the progression of hepatocellular carcinoma. Cancer cell international, 21(1), 1-17.

Tao, M., Luo, J., Gu, T., Yu, X., Song, Z., Jun, Y., ... & Wang, Q. (2021). LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma. Cell death & disease, 12(9), 845.

Wang, K., Wu, Z., Si, Y., Tang, W., Xu, X., Cheng, Y., & Lin, J. (2021). Identification of LPCAT1 expression as a potential prognostic biomarker guiding treatment choice in acute myeloid leukemia. Oncology Letters, 21(2), 1-1.

Ji, W., Peng, Z., Sun, B., Chen, L., Zhang, Q., Guo, M., & Su, C. (2021). LpCat1 promotes malignant transformation of hepatocellular carcinoma cells by directly suppressing STAT1. Frontiers in Oncology, 11, 678714.

Liu, Y., Yang, C., Zhang, Z., & Jiang, H. (2021). Gut microbiota dysbiosis accelerates prostate cancer progression through increased LPCAT1 expression and enhanced DNA repair pathways. Frontiers in oncology, 11, 679712.

Han, C., Yu, G., Mao, Y., Song, S., Li, L., Zhou, L., ... & Xu, B. (2020). LPCAT1 enhances castration resistant prostate cancer progression via increased mRNA synthesis and PAF production. PLoS One, 15(11), e0240801.

Wei, C., Dong, X., Lu, H., Tong, F., Chen, L., Zhang, R., ... & Dong, X. (2019). LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway. Journal of Experimental & Clinical Cancer Research, 38(1), 1-16.

Lebok, P., von Hassel, A., Meiners, J., Hube-Magg, C., Simon, R., Höflmayer, D., ... & Burandt, E. C. (2019). Up-regulation of lysophosphatidylcholine acyltransferase 1 (LPCAT1) is linked to poor prognosis in breast cancer. Aging (Albany NY), 11(18), 7796.

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For research use only. Not intended for any clinical use.

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