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Mouse Anti-LOXL1 Recombinant Antibody (CBYCL-429) (CBMAB-L0330-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCL-429
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH7.4, with 0.02% sodium azide, 50% glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 369-574

Target

Full Name
lysyl oxidase like 1
Introduction
LOXL1 is a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome.
Entrez Gene ID
4016
UniProt ID
Q08397
Alternative Names
LOL; LOXL
Function
Active on elastin and collagen substrates.
Biological Process
Aorta developmentIEA:Ensembl
Collagen fibril organizationManual Assertion Based On ExperimentIBA:GO_Central
Peptidyl-lysine oxidationManual Assertion Based On ExperimentIBA:GO_Central
Protein deaminationManual Assertion Based On ExperimentTAS:UniProtKB
Response to lipopolysaccharideIEA:Ensembl
Cellular Location
Secreted, extracellular space
Involvement in disease
Exfoliation syndrome (XFS):
A disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues.
PTM
The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
More Infomation

Rosell-García, T., Rivas-Muñoz, S., Colige, A., & Rodriguez-Pascual, F. (2022). Cleavage of LOXL1 by BMP1 and ADAMTS14 Proteases Suggests a Role for Proteolytic Processing in the Regulation of LOXL1 Function. International Journal of Molecular Sciences, 23(6), 3285.

Sflomos, G., Battista, L., Aouad, P., De Martino, F., Scabia, V., Stravodimou, A., ... & Brisken, C. (2021). Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1. EMBO Molecular Medicine, 13(3), e13180.

Yang, A., Yan, X., Xu, H., Fan, X., Zhang, M., Huang, T., ... & You, H. (2021). Selective depletion of hepatic stellate cells‐specific LOXL1 alleviates liver fibrosis. The FASEB Journal, 35(10), e21918.

Li, Y., Nie, N., Gong, L., Bao, F., An, C., Cai, H., ... & Zou, X. (2021). Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and Loxl1 deficient mice. Aging (Albany NY), 13(24), 25886.

Yu, H., Ding, J., Zhu, H., Jing, Y., Zhou, H., Tian, H., ... & Wang, X. (2020). LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2. Cell Death & Differentiation, 27(11), 3021-3036.

Hu, L., Wang, J., Wang, Y., Wu, L., Wu, C., Mao, B., ... & Chin, Y. E. (2020). LOXL1 modulates the malignant progression of colorectal cancer by inhibiting the transcriptional activity of YAP. Cell Communication and Signaling, 18, 1-16.

Zeltz, C., Pasko, E., Cox, T. R., Navab, R., & Tsao, M. S. (2019). LOXL1 is regulated by integrin α11 and promotes non-small cell lung cancer tumorigenicity. Cancers, 11(5), 705.

Sun, Q., Li, J., Li, F., Li, H., Bei, S., Zhang, X., & Feng, L. (2019). LncRNA LOXL1‐AS1 facilitates the tumorigenesis and stemness of gastric carcinoma via regulation of miR‐708‐5p/USF1 pathway. Cell proliferation, 52(6), e12687.

Chen, S., Li, W., & Guo, A. (2019). LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma. Bioscience Reports, 39(4), BSR20190447.

Bernstein, A. M., Ritch, R., & Wolosin, J. M. (2019). LOXL1 folding in exfoliation glaucoma. Advances in protein chemistry and structural biology, 118, 273-288.

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For research use only. Not intended for any clinical use.

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