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Mouse Anti-LOR Recombinant Antibody (CBYCL-423) (CBMAB-L0324-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCL-423
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Loricrin
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH7.4, with 0.02% sodium azide, 50% glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Loricrin
Introduction
Loricrin is a protein that in humans is encoded by the LOR gene. Loricrin is a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells.
Entrez Gene ID
4014
UniProt ID
P23490
Alternative Names
loricrin
Function
Major keratinocyte cell envelope protein.
Biological Process
KeratinizationIEA:UniProtKB-KW
Keratinocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Peptide cross-linkingManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Nucleus, nucleoplasm
Involvement in disease
Vohwinkel syndrome with ichthyosis (VSI):
A variant form of Vohwinkel syndrome without hearing loss and associated with ichthyosiform dermatosis. Clinical features include palmoplantar keratoderma, pseudoainhum and ichthyosis. Compact hyperkeratosis with round retained nuclei and hypergranulosis is observed on skin biopsies.
PTM
Substrate of transglutaminases. Some glutamines and lysines are cross-linked to other loricrin molecules and to SPRRs proteins.
Contains inter- or intramolecular disulfide-bonds.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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