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Mouse Anti-LCP2 Recombinant Antibody (SLP-76-03) (CBMAB-L0903-YJ)


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Summary

Host Animal
Mouse
Specificity
Human, Pig, Mouse
Clone
SLP-76-03
Antibody Isotype
IgG2b
Application
IHC-P, WB

Basic Information

Immunogen
Bacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag.
Specificity
Human, Pig, Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 216-434

Target

Full Name
LCP2
Introduction
LCP2 is an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability.
Entrez Gene ID
Human3937
Mouse16822
Pig100511843
UniProt ID
HumanQ13094
MouseQ60787
PigF1RRX4
Alternative Names
SLP-76; SLP76
Function
Involved in T-cell antigen receptor mediated signaling.
Biological Process
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Mast cell activationIEA:Ensembl
Positive regulation of protein kinase activityManual Assertion Based On ExperimentIEP:CACAO
T cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
PTM
Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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