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Mouse Anti-LCP2 Recombinant Antibody (CBYCL-175) (CBMAB-L0076-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCL-175
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Lyophilized from PBS, pH7.4, with 5% trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-533

Target

Full Name
LCP2
Introduction
LCP2 is an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation.
Entrez Gene ID
3937
UniProt ID
Q13094
Alternative Names
SLP-76; SLP76
Function
Involved in T-cell antigen receptor mediated signaling.
Biological Process
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Mast cell activationIEA:Ensembl
Positive regulation of protein kinase activityManual Assertion Based On ExperimentIEP:CACAO
T cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
PTM
Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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