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Mouse Anti-LAMA3 Recombinant Antibody (CBYCL-138) (CBMAB-L0039-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCL-138
Antibody Isotype
IgG1
Application
ELISA, ICC, IHC, IP, WB

Basic Information

Immunogen
Human keratinocytes
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
laminin subunit alpha 3
Introduction
LAMA3 belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome.
Entrez Gene ID
3909
UniProt ID
Q16787
Alternative Names
AI429800; Lnk
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Endodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Morphogenesis of a polarized epitheliumManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell adhesionIEA:InterPro
Regulation of cell migrationIEA:InterPro
Regulation of embryonic developmentIEA:InterPro
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
Major component.
Involvement in disease
Epidermolysis bullosa, junctional, Herlitz type (H-JEB):
An infantile and lethal form of junctional epidermolysis bullosa, a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement In the Herlitz type, death occurs usually within the first six months of life. Occasionally, children survive to teens. It is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic.
Laryngoonychocutaneous syndrome (LOCS):
Autosomal recessive epithelial disorder confined to the Punjabi Muslim population. The condition is characterized by cutaneous erosions, nail dystrophy and exuberant vascular granulation tissue in certain epithelia, especially conjunctiva and larynx.
More Infomation

Shu, C., Wang, W., Wu, L., Qi, C., Yan, W., Lu, W., ... & Shang, A. (2023). LINC00936/MicroRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3. Recent Patents on Anti-Cancer Drug Discovery, 18(1), 66-79.

Wang, S. K., Zhang, H., Wang, Y. L., Seymen, F., Koruyucu, M., Simmer, J. P., & Hu, J. C. C. (2022). Phenotypic variability in LAMA3‐associated amelogenesis imperfecta. Oral Diseases.

Tian, C., Li, X., & Ge, C. (2021). High expression of LAMA3/AC245041. 2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis. Molecular Medicine, 27(1), 62.

Herrmann, I., Linder, K. E., Meurs, K. M., Friedenberg, S. G., Cullen, J., Olby, N., & Bizikova, P. (2021). Canine junctional epidermolysis bullosa due to a novel mutation in LAMA3 with severe upper respiratory involvement. Veterinary dermatology, 32(4), 379-e108.

Li, Y., Zhang, J., Cheng, Z., Wang, Y., Huang, T., Lai, K., ... & Yang, G. (2020). Adenovirus-mediated LAMA3 transduction enhances hemidesmosome formation and periodontal reattachment during wound healing. Molecular Therapy-Methods & Clinical Development, 18, 291-303.

Tang, L., Wang, P., Wang, Q., & Zhong, L. (2019). Correlation of LAMA3 with onset and prognosis of ovarian cancer. Oncology Letters, 18(3), 2813-2818.

Xu, S. F., Zheng, Y., Zhang, L., Wang, P., Niu, C. M., Wu, T., ... & Gao, L. M. (2019). Long non-coding RNA LINC00628 interacts epigenetically with the LAMA3 promoter and contributes to lung adenocarcinoma. Molecular Therapy-Nucleic Acids, 18, 166-182.

Zhang, J., Wang, H., Wang, Y., Dong, W., Jiang, Z., & Yang, G. (2018). Substrate-mediated gene transduction of LAMA3 for promoting biological sealing between titanium surface and gingival epithelium. Colloids and Surfaces B: Biointerfaces, 161, 314-323.

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For research use only. Not intended for any clinical use.

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