Mouse Anti-KRT7 Recombinant Antibody (CBYY-C2623) (CBMAB-C4064-YY)

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Summary

Host Animal

Mouse

Specificity

Cattle, Human, Pig, Sheep

Clone

CBYY-C2623

Antibody Isotype

IgG1

Application

IHC, WB

Basic Information

Immunogen

Cytoskeletal proteins from cultured HeLa cells

Specificity

Cattle, Human, Pig, Sheep

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Protein A purified

Buffer

0.05 mg/mL

Preservative

PBS, pH 7.4, 0.5% BSA

Concentration

Lyophilized

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Keratin 7

Entrez Gene ID

Human	3855
Cattle	535697
Pig	100626722
Sheep	101112716

UniProt ID

Human	P08729
Cattle	Q29S21
Pig	A0A287AG48
Sheep	W5Q6V2

Alternative Names

Keratin 7; Sarcolectin; Keratin, 55K Type II Cytoskeletal; Keratin, Type II Cytoskeletal 7; Type-II Keratin Kb7; Keratin 7, Type II; Cytokeratin 7; CK-7; SCL;

Function

Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).

Cellular Location

Cytoplasm

PTM

Arg-20 is dimethylated, probably to asymmetric dimethylarginine.

More Infomation

References

Zhao, Z., Meng, M., Yao, J., Zhou, H., Chen, Y., Liu, J., ... & Zhou, Q. (2023). The long non-coding RNA keratin-7 antisense acts as a new tumor suppressor to inhibit tumorigenesis and enhance apoptosis in lung and breast cancers. Cell Death & Disease, 14(4), 293.

Dariane, C., Clairefond, S., Péant, B., Communal, L., Thian, Z., Ouellet, V., ... & Saad, F. (2022). High Keratin-7 Expression in Benign Peri-Tumoral Prostatic Glands Is Predictive of Bone Metastasis Onset and Prostate Cancer-Specific Mortality. Cancers, 14(7), 1623.

Lin, M., Wang, J., Wang, S., & Huang, Y. (2022). Expression level of keratin 7 in epithelial ovarian cancer and malignant metastasis of benign epithelial ovarian tumors. Cellular and Molecular Biology, 68(2), 153-161.

Communal, L., Roy, N., Cahuzac, M., Rahimi, K., Köbel, M., Provencher, D. M., & Mes-Masson, A. M. (2021). A Keratin 7 and E-Cadherin Signature Is Highly Predictive of Tubo-Ovarian High-Grade Serous Carcinoma Prognosis. International Journal of Molecular Sciences, 22(10), 5325.

An, Q., Liu, T., Wang, M. Y., Yang, Y. J., Zhang, Z. D., Liu, Z. J., & Yang, B. (2021). KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway. Oncology reports, 45(2), 481-492.

Li, Y., Su, Z., Wei, B., & Liang, Z. (2021). KRT7 overexpression is associated with poor prognosis and immune cell infiltration in patients with pancreatic adenocarcinoma. International Journal of General Medicine, 2677-2694.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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