Mouse Anti-KRT7 Recombinant Antibody (CBYY-C2622) (CBMAB-C4063-YY)

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Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-C2622

Antibody Isotype

IgG2b

Application

IF, WB

Basic Information

Immunogen

Purified recombinant human Cytokeratin 7 protein fragments expressed in E.coli

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Affinity purified

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Keratin 7

Entrez Gene ID

3855

UniProt ID

P08729

Alternative Names

Keratin 7; Sarcolectin; Keratin, 55K Type II Cytoskeletal; Keratin, Type II Cytoskeletal 7; Type-II Keratin Kb7; Keratin 7, Type II; Cytokeratin 7; CK-7; SCL;

Function

Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).

Cellular Location

Cytoplasm

PTM

Arg-20 is dimethylated, probably to asymmetric dimethylarginine.

More Infomation

References

Zhao, Z., Meng, M., Yao, J., Zhou, H., Chen, Y., Liu, J., ... & Zhou, Q. (2023). The long non-coding RNA keratin-7 antisense acts as a new tumor suppressor to inhibit tumorigenesis and enhance apoptosis in lung and breast cancers. Cell Death & Disease, 14(4), 293.

Dariane, C., Clairefond, S., Péant, B., Communal, L., Thian, Z., Ouellet, V., ... & Saad, F. (2022). High Keratin-7 Expression in Benign Peri-Tumoral Prostatic Glands Is Predictive of Bone Metastasis Onset and Prostate Cancer-Specific Mortality. Cancers, 14(7), 1623.

Lin, M., Wang, J., Wang, S., & Huang, Y. (2022). Expression level of keratin 7 in epithelial ovarian cancer and malignant metastasis of benign epithelial ovarian tumors. Cellular and Molecular Biology, 68(2), 153-161.

Communal, L., Roy, N., Cahuzac, M., Rahimi, K., Köbel, M., Provencher, D. M., & Mes-Masson, A. M. (2021). A Keratin 7 and E-Cadherin Signature Is Highly Predictive of Tubo-Ovarian High-Grade Serous Carcinoma Prognosis. International Journal of Molecular Sciences, 22(10), 5325.

An, Q., Liu, T., Wang, M. Y., Yang, Y. J., Zhang, Z. D., Liu, Z. J., & Yang, B. (2021). KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway. Oncology reports, 45(2), 481-492.

Li, Y., Su, Z., Wei, B., & Liang, Z. (2021). KRT7 overexpression is associated with poor prognosis and immune cell infiltration in patients with pancreatic adenocarcinoma. International Journal of General Medicine, 2677-2694.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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