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Mouse Anti-KRT2 (N-terminus) Recombinant Antibody (CBYY-C2610) (CBMAB-C4051-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Frog
Clone
CBYY-C2610
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Immunogen
Synthetic peptide (N-terminal amino acids Nos. 2-23) of human cytokeratin 2e (MW 65,852)
Specificity
Human, Frog
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-terminus

Target

Full Name
Keratin 2
Entrez Gene ID
3849
UniProt ID
P35908
Function
Probably contributes to terminal cornification (PubMed:1380918).
Associated with keratinocyte activation, proliferation and keratinization (PubMed:12598329).
Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).
Biological Process
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Intermediate filament organizationIEA:Ensembl
KeratinizationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte activationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte developmentIEA:Ensembl
Keratinocyte migrationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Peptide cross-linkingManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of epidermis developmentISS:UniProtKB
Cellular Location
Cornified envelope
Cytosol
Extracellular exosome
Extracellular space
Intermediate filament
Keratin filament
Membrane
Nucleus
Involvement in disease
Ichthyosis bullosa of Siemens (IBS):
A rare autosomal dominant skin disorder displaying a type of epidermolytic hyperkeratosis characterized by generalized erythema and extensive blistering from birth. Large, dark gray hyperkeratoses are observed in later weeks. The skin of IBS patients is unusually fragile and has a tendency to shed the outer layers of the epidermis, producing localized denuded areas (molting effect). IBS usually improves with age so that in most middle-aged patients the hyperkeratosis and keratotic lichenification is limited to the flexural folds of the major joints.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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