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Mouse Anti-KRT19 Monoclonal Antibody (3F8) (CBMAB-0978-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Dog, Monkey, Rat
Clone
3F8
Antibody Isotype
IgG1
Application
ICC, IF, IHC, IHC-P, WB

Basic Information

Immunogen
Recombinant fragment expressed in E.coli corresponding to amino acids 240-390 of human CK19
Specificity
Human, Dog, Monkey, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Keratin 19
Introduction
The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 is a member of the keratin family and it is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis.
Entrez Gene ID
Human3880
Mouse16669
Dog100685481
Monkey707129
UniProt ID
HumanP08727
MouseP19001
DogA7XZY9
MonkeyA0A2K5W9Q7
Alternative Names
Keratin 19; 40-KDa Keratin Intermediate Filament; Keratin, Type I Cytoskeletal 19; Keratin, Type I, 40-Kd; Keratin 19, Type I; Cytokeratin 19; CK-19;
Function
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Biological Process
Cell differentiation involved in embryonic placenta development Source: Ensembl
Cornification Source: Reactome
Keratinization Source: Reactome
Notch signaling pathway Source: Ensembl
Response to estrogen Source: UniProtKB
Sarcomere organization Source: UniProtKB
Viral process Source: UniProtKB-KW
Cellular Location
Intermediate filament; Terminal web; Cytosol; Extracellular exosome; Apicolateral plasma membrane; Dystrophin-associated glycoprotein complex; Plasma membrane; Sarcolemma; Cell periphery; Costamere; Z disc
More Infomation

Krüger, J., Fischer, A., Breunig, M., Allgöwer, C., Schulte, L., Merkle, J., ... & Kleger, A. (2023). DNA methylation‐associated allelic inactivation regulates Keratin 19 gene expression during pancreatic development and carcinogenesis. The Journal of Pathology, 261(2), 139-155.

Wang, Z., Moresco, P., Yan, R., Li, J., Gao, Y., Biasci, D., ... & Fearon, D. T. (2022). Carcinomas assemble a filamentous CXCL12–keratin-19 coating that suppresses T cell–mediated immune attack. Proceedings of the National Academy of Sciences, 119(4), e2119463119.

Alsharif, S., Sharma, P., Bursch, K., Milliken, R., Lam, V., Fallatah, A., ... & Chung, B. M. (2021). Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells. Cell adhesion & migration, 15(1), 1-17.

Rhee, H., Kim, H., & Park, Y. N. (2020). Clinico-radio-pathological and molecular features of hepatocellular carcinomas with keratin 19 expression. Liver Cancer, 9(6), 663-681.

Lam, V. K., Sharma, P., Nguyen, T., Nehmetallah, G., Raub, C. B., & Chung, B. M. (2020). Morphology, motility, and cytoskeletal architecture of breast cancer cells depend on keratin 19 and substrate. Cytometry Part A, 97(11), 1145-1155.

Yokomichi, N., Nishida, N., Umeda, Y., Taniguchi, F., Yasui, K., Toshima, T., ... & Nagasaka, T. (2019). Heterogeneity of epigenetic and epithelial mesenchymal transition marks in hepatocellular carcinoma with keratin 19 proficiency. Liver cancer, 8(4), 239-254.

Sharma, P., Alsharif, S., Bursch, K., Parvathaneni, S., Anastasakis, D. G., Chahine, J., ... & Chung, B. M. (2019). Keratin 19 regulates cell cycle pathway and sensitivity of breast cancer cells to CDK inhibitors. Scientific reports, 9(1), 14650.

Rhee, H., Kim, H. Y., Choi, J. H., Woo, H. G., Yoo, J. E., Nahm, J. H., ... & Park, Y. N. (2018). Keratin 19 expression in hepatocellular carcinoma is regulated by fibroblast-derived HGF via a MET-ERK1/2-AP1 and SP1 axis. Cancer research, 78(7), 1619-1631.

Palkó, E., Póliska, S., Sziklai, I., & Penyige, A. (2018). Analysis of KRT1, KRT10, KRT19, TP53 and MMP9 expression in pediatric and adult cholesteatoma. PLoS One, 13(7), e0200840.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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