Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-KRT16 Recombinant Antibody (EC117) (V2LY-0624-LY117)


See all KRT16 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
EC117
Antibody Isotype
IgG
Application
IHC-P, IF

Basic Information

Immunogen
Synthetic Peptide.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IHC-P1:100-1:300
IF(CC)1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
>95% by SDS Page
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Keratin 16
Introduction
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
Entrez Gene ID
Human3868
Mouse16666
Rat303530
UniProt ID
HumanP08779
MouseQ9Z2K1
RatQ6IFU9
Alternative Names
Keratin 16; Focal Non-Epidermolytic Palmoplantar Keratoderma; Keratin 16, Type I; KRT16A; K16; Keratin, Type I Cytoskeletal 16; Cytokeratin 16; Cytokeratin-16;
Function
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
Biological Process
AgingManual Assertion Based On ExperimentIDA:UniProtKB
Cytoskeleton organization1 PublicationNAS:UniProtKB
Establishment of skin barrierISS:UniProtKB
Hair cycleManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseISS:UniProtKB
Innate immune responseISS:UniProtKB
Intermediate filament cytoskeleton organizationIEA:Ensembl
KeratinizationISS:UniProtKB
Keratinocyte differentiationISS:UniProtKB
Keratinocyte migrationISS:UniProtKB
Morphogenesis of an epitheliumISS:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoskeleton
Cytosol
Extracellular exosome
Intermediate filament
Nucleus
Involvement in disease
Pachyonychia congenita 1 (PC1):
An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.
Keratoderma, palmoplantar, non-epidermolytic, focal 1 (FNEPPK1):
A dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are often present.
KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
More Infomation

Lu, Z., Peng, H., Li, R., Xu, X., & Peng, J. (2022). BarH-like homeobox 2 represses the transcription of keratin 16 and affects Ras signaling pathway to suppress nasopharyngeal carcinoma progression. Bioengineered, 13(2), 3122-3136.

Elazezy, M., Schwentesius, S., Stegat, L., Wikman, H., Werner, S., Mansour, W. Y., ... & Joosse, S. A. (2021). Emerging insights into keratin 16 expression during metastatic progression of breast cancer. Cancers, 13(15), 3869.

Zhang, X., Yin, M., & Zhang, L. J. (2019). Keratin 6, 16 and 17—critical barrier alarmin molecules in skin wounds and psoriasis. Cells, 8(8), 807.

Huang, W. C., Jang, T. H., Tung, S. L., Yen, T. C., Chan, S. H., & Wang, L. H. (2019). A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway. Journal of Experimental & Clinical Cancer Research, 38, 1-17.

Zieman, A. G. (2018). A role for keratin 16 in the regulation of epithelial differentiation and homeostasis in glabrous epidermis (Doctoral dissertation, Johns Hopkins University).

Zieman, A., & Coulombe, P. A. (2018). The keratin 16 null phenotype is modestly impacted by genetic strain background in mice. Experimental dermatology, 27(6), 672-674.

Zhang, J., Li, X., Chen, H., Lu, Y., Li, L., Han, L., & Lu, C. (2018). Gallic acid inhibits the expression of keratin 16 and keratin 17 through Nrf2 in psoriasis-like skin disease. International Immunopharmacology, 65, 84-95.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-KRT16 Recombinant Antibody (EC117)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry