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Mouse Anti-KRT13 Recombinant Antibody (CBWJC-3985) (CBMAB-C5297WJ)


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Summary

Host Animal
Mouse
Specificity
Dog, Human, Zebrafish
Clone
CBWJC-3985
Antibody Isotype
IgG2a
Application
IHC-Fr, ICC, WB, FC, IHC-P

Basic Information

Specificity
Dog, Human, Zebrafish
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Keratin 13
Introduction
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human3860
Dog490983
UniProt ID
HumanP13646
Alternative Names
Keratin 13; Keratin, Type I Cytoskeletal 13; Keratin 13, Type I; Cytokeratin 13; CK-13; K13;
Biological Process
Cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytosol
Extracellular exosome
Intermediate filament cytoskeleton
Keratin filament
Nucleus
Involvement in disease
White sponge nevus 2 (WSN2):
A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
PTM
O-glycosylated; glycans consist of single N-acetylglucosamine residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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