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Mouse Anti-KRT1 Recombinant Antibody (KRT/457) (CBMAB-P0455-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Pig, Cattle, Guinea pig, Goat, Monkey
Clone
KRT/457
Antibody Isotype
IgG1
Application
WB, FC, IHC-P, IF, CyTOF

Basic Information

Specificity
Human, Mouse, Rat, Pig, Cattle, Guinea pig, Goat, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Keratin 1
Introduction
KRT1 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Entrez Gene ID
Human3848
Mouse16678
Rat300250
Pig100049664
Cattle100301161
Guinea pig100714242
Goat102175951
Monkey699320
UniProt ID
HumanP04264
MouseP04104
RatQ6IMF3
PigF1SGG3
CattleG3N0V2
Guinea pigH0VAR5
GoatA0A452GA47
MonkeyA0A2K5U960
Alternative Names
CK1; EHK; EHK1; EPPK; K1; KRT1A; NEPPK
Function
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
Biological Process
Complement activation, lectin pathwayManual Assertion Based On ExperimentIPI:UniProtKB
Establishment of skin barrierIEA:Ensembl
Fibrinolysis1 PublicationNAS:UniProtKB
Negative regulation of inflammatory responseIEA:Ensembl
Peptide cross-linkingManual Assertion Based On ExperimentIDA:CAFA
Protein heterotetramerizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of angiogenesis1 PublicationNAS:UniProtKB
Response to oxidative stress1 PublicationNAS:UniProtKB
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Cell membrane
Located on plasma membrane of neuroblastoma NMB7 cells.
Involvement in disease
Epidermolytic hyperkeratosis (EHK):
An autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
Ichthyosis hystrix, Curth-Macklin type (IHCM):
A genodermatosis with severe verrucous hyperkeratosis. Affected individuals manifest congenital verrucous black scale on the scalp, neck, and limbs with truncal erythema, palmoplantar keratoderma and keratoses on the lips, ears, nipples and buttocks.
Keratoderma, palmoplantar, non-epidermolytic (NEPPK):
A dermatological disorder characterized by well-demarcated hyperkeratosis is present over the palms and soles. A red band is frequently present at the periphery of the keratosis. It is usually non-transgredient, with a sharp demarcation of the lesions at the wrists.
Ichthyosis annular epidermolytic (AEI):
A skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
Keratoderma, palmoplantar, striate 3 (SPPK3):
A dermatological disorder characterized by thickening of the stratum corneum and epidermal layers on palms and soles. There is no involvement of non-palmoplantar skin, and both hair and nails are normal.
PTM
Undergoes deimination of some arginine residues (citrullination).
More Infomation

Cheng, C. W., Fang, W. F., & Lin, J. D. (2023). Associations of serum keratin 1 with thyroid function and immunity in Graves’ disease. Plos one, 18(11), e0289345.

Affolter, V. K., Kiener, S., Jagannathan, V., Nagle, T., & Leeb, T. (2022). A de novo variant in the keratin 1 gene (KRT1) in a Chinese shar-pei dog with severe congenital cornification disorder and non-epidermolytic ichthyosis. PloS one, 17(10), e0275367.

Mo, R., Lin, M., Lee, M., Yan, W., Wang, H., & Lin, Z. (2022). Nonsense mutations in KRT1 caused recessive epidermolytic palmoplantar keratoderma with knuckle pads. Journal of the European Academy of Dermatology and Venereology, 36(10), 1857-1862.

Wu, J., Niu, J., Li, M., & Miao, Y. (2021). Keratin 1 maintains the intestinal barrier in ulcerative colitis. Genes & Genomics, 43, 1389-1402.

Han, W., Hu, C., Fan, Z. J., & Shen, G. L. (2021). Transcript levels of keratin 1/5/6/14/15/16/17 as potential prognostic indicators in melanoma patients. Scientific Reports, 11(1), 1023.

Zhang, L., Zeng, X. X., Li, Y. M., Chen, S. K., Tang, L. Y., Wang, N., ... & Lin, M. J. (2021). Keratin 1 attenuates hypoxic pulmonary artery hypertension by suppressing pulmonary artery media smooth muscle expansion. Acta Physiologica, 231(2), e13558.

Smith, F. J. D., Kreuser‐Genis, I. M., Jury, C. S., Wilson, N. J., Terron‐Kwiatowski, A., & Zamiri, M. (2019). Novel and recurrent mutations in keratin 1 cause epidermolytic ichthyosis and palmoplantar keratoderma. Clinical and experimental dermatology, 44(5), 528-534.

Terrinoni, A., Didona, B., Caporali, S., Chillemi, G., Lo Surdo, A., Paradisi, M., ... & Melino, G. (2018). Role of the keratin 1 and keratin 10 tails in the pathogenesis of ichthyosis hystrix of Curth Macklin. PLoS One, 13(4), e0195792.

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For research use only. Not intended for any clinical use.

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