Mouse Anti-KLRK1 Recombinant Antibody (CBYY-C0357) (CBMAB-C1212-YY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-C0357

Antibody Isotype

IgG2a

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Preservative

PBS

Concentration

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Killer Cell Lectin Like Receptor K1

Entrez Gene ID

22914

UniProt ID

P26718

Alternative Names

Inducible T Cell Costimulator

Function

Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Cell differentiationIEA:UniProtKB-KW
Cellular response to lipopolysaccharideIEA:Ensembl
Defense response to Gram-positive bacteriumIEA:Ensembl
Natural killer cell activationManual Assertion Based On ExperimentTAS:BHF-UCL
Natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of GTPase activityManual Assertion Based On ExperimentIDA:CACAO
Negative regulation of natural killer cell chemotaxisManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of interferon-gamma productionIEA:Ensembl
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of nitric oxide biosynthetic processIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Stimulatory C-type lectin receptor signaling pathwayIEA:Ensembl
T cell costimulationManual Assertion Based On ExperimentTAS:BHF-UCL

Cellular Location

Cell membrane
Colocalized with HCST on the cell surface.

Topology

Cytoplasmic: 1-51
Helical: 52-72
Extracellular: 73-216

More Infomation

References

Tan, H., Yang, H., Qian, J., Liu, S., Yan, D., Wei, L., & Liu, W. (2023). Involvement of KLRK1 in immune infiltration of head and neck squamous cell carcinoma correlates with favorable prognosis. Medicine, 102(32), e34761.

Weiss, E., Schrüfer, A., Tocantins, C., Diniz, M. S., Novakovic, B., van Bergen, A. S., ... & Hiden, U. (2023). Higher gestational weight gain delays wound healing and reduces expression of long non‐coding RNA KLRK1‐AS1 in neonatal endothelial progenitor cells. The Journal of Physiology, 601(17), 3961-3974.

Tsyklauri, O., Chadimova, T., Niederlova, V., Kovarova, J., Michalik, J., Malatova, I., ... & Stepanek, O. (2023). Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2. Elife, 12, e79342.

Zhang, Y., Chen, Z., Jiang, A., & Gao, G. (2022). KLRK1 as a prognostic biomarker for lung adenocarcinoma cancer. Scientific Reports, 12(1), 1976.

Wang, J., Dai, Z., Miao, Y., Zhao, T., Gan, J., Zhao, C., ... & Guan, Q. (2021). Carbon ion (12C6+) irradiation induces the expression of Klrk1 in lung cancer and optimizes the tumor microenvironment based on the NKG2D/NKG2D-Ls pathway. Cancer Letters, 521, 178-195.

von Linsingen, R., de França, P. P., de Carvalho, N. S., & da Graça Bicalho, M. (2020). MICA and KLRK1 genes and their impact in cervical intraepithelial neoplasia development in the southern Brazilian population. Human Immunology, 81(5), 249-253.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Datasheet
SDS
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Second antibody and isotype control

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