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Mouse Anti-KLRB1 Recombinant Antibody (6A381) (CBMAB-C8022-LY)


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Summary

Host Animal
Mouse
Specificity
Rat
Clone
6A381
Antibody Isotype
IgG1
Application
FC, IHC, IP

Basic Information

Immunogen
Purified splenic NK cells from the LEW rat strain
Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killer Cell Lectin Like Receptor B1
Introduction
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
Entrez Gene ID
689817
UniProt ID
Q5NKN4
Function
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Biological Process
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Topology
Cytoplasmic: 1-44
Helical: 45-66
Extracellular: 67-225
PTM
N-glycosylated. Contains sialic acid residues.
More Infomation

Xu, N., Meng, X., Chu, H., Yang, Z., Jiao, Y., & Li, Y. (2023). The prognostic significance of KLRB1 and its further association with immune cells in breast cancer. PeerJ, 11, e15654.

Huang, G., Xiao, S., Jiang, Z., Zhou, X., Chen, L., Long, L., ... & Jiang, B. (2023). Machine learning immune-related gene based on KLRB1 model for predicting the prognosis and immune cell infiltration of breast cancer. Frontiers in Endocrinology, 14, 1185799.

Cheng, X., Cao, Y., Wang, X., Cheng, L., Liu, Y., Lei, J., ... & Shi, D. (2022). Systematic pan-cancer analysis of KLRB1 with prognostic value and immunological activity across human tumors. Journal of immunology research, 2022.

Di, W., Fan, W., Wu, F., Shi, Z., Wang, Z., Yu, M., ... & Zhang, W. (2022). Clinical characterization and immunosuppressive regulation of CD161 (KLRB1) in glioma through 916 samples. Cancer Science, 113(2), 756-769.

Hachim, M., Hachim, I., & Hannawi, S. (2022). Killer cell lectin-like receptor subfamily B member 1 (KLRB1), lymphocyte function-associated antigen 3 (CD58), and Niban1 (FAM129A) are unique markers for developed (central and effector) memory T cells in rheumatoid arthritis. Saudi Medical Journal, 43(6).

Lu, J., Bi, Y., Zhu, Y., Huipeng, S., Duan, W., & Zhou, J. (2021). CD3D, GZMK, and KLRB1 are potential markers for early diagnosis of rheumatoid arthritis, especially in anti-citrullinated protein antibody-negative patients. Frontiers in Pharmacology, 12, 726529.

Zhang, G., Liu, Y., Dong, F., & Liu, X. (2020). Transcription/expression of KLRB1 gene as a prognostic indicator in human esophageal squamous cell carcinoma. Combinatorial Chemistry & High Throughput Screening, 23(7), 667-674.

Thude, H., Rother, S., Sterneck, M., Klempnauer, J., Nashan, B., Schwinzer, R., & Koch, M. (2018). The killer cell lectin‐like receptor B1 (KLRB1) 503T> C polymorphism (rs1135816) and acute rejection after liver transplantation. Hla, 91(1), 52-55.

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For research use only. Not intended for any clinical use.

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