Mouse Anti-KLK3 Monoclonal Antibody (CBFYR0452) (CBMAB-R0452-FY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYR0452

Antibody Isotype

IgG1, κ

Application

ELISA

Basic Information

Immunogen

Human Prostate Specific antigen (PSA)

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Kallikrein Related Peptidase 3

Introduction

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene.

Entrez Gene ID

354

UniProt ID

P07288

Alternative Names

Prostate Specific antigen; PSA

Function

Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Biological Process

Cellular protein metabolic processTAS:Reactome
Negative regulation of angiogenesis1 PublicationNAS:UniProtKB
Positive regulation of antibacterial peptide productionManual Assertion Based On ExperimentIDA:UniProtKB
ProteolysisManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of systemic arterial blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Zymogen activationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted

More Infomation

References

Raimondo, S., Gentile, M., Esposito, G., Gentile, T., Ferrara, I., Crescenzo, C., ... & Montano, L. (2021). Could kallikrein-related serine peptidase 3 be an early biomarker of environmental exposure in young women?. International Journal of Environmental Research and Public Health, 18(16), 8833.

Koistinen, H., Künnapuu, J., & Jeltsch, M. (2021). KLK3 in the Regulation of Angiogenesis—Tumorigenic or Not?. International Journal of Molecular Sciences, 22(24), 13545.

Motamedi, R. K., Sarhangi, N., Afshari, M., Sattari, M., Jamaldini, S. H., Samzadeh, M., ... & Hasanzad, M. (2019). Kallikarein‐related peptidase 3 common genetic variant and the risk of prostate cancer. Journal of Cellular Biochemistry, 120(9), 14822-14830.

Ding, W. H., Ren, K. W., Yue, C., Zou, J. G., Zuo, L., Zhang, L. F., ... & Mi, Y. Y. (2018). Association between three genetic variants in kallikrein 3 and prostate cancer risk. Bioscience reports, 38(6), BSR20181151.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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