Rabbit Anti-KLK3 Recombinant Antibody (7) (CBMAB-A4535-YC)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

Antibody Isotype

IgG

Application

ELISA

Basic Information

Immunogen

Recombinant Human KLK3/Kallikrein 3 protein.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Kallikrein Related Peptidase 3

Introduction

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one

Entrez Gene ID

354

UniProt ID

P07288

Alternative Names

APS; KLK2A1; PSA; hK3

Function

Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Biological Process

Cellular protein metabolic processTAS:Reactome
Negative regulation of angiogenesis1 PublicationNAS:UniProtKB
Positive regulation of antibacterial peptide productionManual Assertion Based On ExperimentIDA:UniProtKB
ProteolysisManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of systemic arterial blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Zymogen activationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted

More Infomation

References

Raimondo, S., Gentile, M., Esposito, G., Gentile, T., Ferrara, I., Crescenzo, C., ... & Montano, L. (2021). Could kallikrein-related serine peptidase 3 be an early biomarker of environmental exposure in young women?. International Journal of Environmental Research and Public Health, 18(16), 8833.

Koistinen, H., Künnapuu, J., & Jeltsch, M. (2021). KLK3 in the Regulation of Angiogenesis—Tumorigenic or Not?. International Journal of Molecular Sciences, 22(24), 13545.

Motamedi, R. K., Sarhangi, N., Afshari, M., Sattari, M., Jamaldini, S. H., Samzadeh, M., ... & Hasanzad, M. (2019). Kallikarein‐related peptidase 3 common genetic variant and the risk of prostate cancer. Journal of Cellular Biochemistry, 120(9), 14822-14830.

Ding, W. H., Ren, K. W., Yue, C., Zou, J. G., Zuo, L., Zhang, L. F., ... & Mi, Y. Y. (2018). Association between three genetic variants in kallikrein 3 and prostate cancer risk. Bioscience reports, 38(6), BSR20181151.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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Second antibody and isotype control

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