Rabbit Anti-KIF13B Recombinant Antibody (EG1788) (CBMAB-EN2136-LY)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

EG1788

Antibody Isotype

IgG

Application

IHC: 1:50~1:100 ELISA: 1:5000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human KIF13B.

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Kinesin Family Member 13B

Introduction

Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.

Entrez Gene ID

23303

UniProt ID

Q9NQT8

Alternative Names

Kinesin Family Member 13B; Kinesin-Like Protein GAKIN; GAKIN; Guanylate Kinase Associated Kinesin; Kinesin-Like Protein KIF13B; Kinesin 13B; KIAA0639;

Function

Biological Process

Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Protein targetingManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of axonogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Signal transduction1 PublicationNAS:UniProtKB
T cell activation1 PublicationNAS:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton; Cell projection, axon. accumulates at the distal part of the microtubules in the tips of axons, but not of dendrites.

PTM

Phosphorylated at Ser-1381 and Ser-1410 by MARK2, promoting interaction with 14-3-3 and inhibiting microtubule-dependent accumulation and formation of axons.

More Infomation

References

Montgomery, A. C., Mendoza, C. S., Garbouchian, A., Quinones, G. B., & Bentley, M. (2023). Polarized vesicle transport requires AP-1-mediated recruitment of KIF13A and KIF13B at the trans-Golgi network. bioRxiv, 2023-04.

Serra-Marques, A., Martin, M., Katrukha, E. A., Grigoriev, I., Peeters, C. A., Liu, Q., ... & Akhmanova, A. (2020). Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends. Elife, 9, e61302.

Liao, E. H., Gray, L., Tsurudome, K., El-Mounzer, W., Elazzouzi, F., Baim, C., ... & Haghighi, A. P. (2018). Kinesin Khc-73/KIF13B modulates retrograde BMP signaling by influencing endosomal dynamics at the Drosophila neuromuscular junction. PLoS genetics, 14(1), e1007184.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-KIF13B Recombinant Antibody (6E11)

Mouse Anti-KIF13B Recombinant Antibody (7H5)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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