Rat Anti-ITGB7 Recombinant Antibody (AG126) (V2LY-0524-LY56)

Name: Rat Anti-ITGB7 Recombinant Antibody (AG126)
SKU: V2LY-0524-LY56
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Rat

Specificity

Human

Clone

AG126

Antibody Isotype

IgG2a, κ

Application

Blocking, CyTOF, FC, IP

Basic Information

Immunogen

TK1 Cells

Host Species

Rat

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

< 1.0 EU/mg as determined by the LAL method

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

5 mg/ml

Purity

>95% by SDS Page

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

integrin beta 7

Entrez Gene ID

3695

UniProt ID

P26010

Alternative Names

Integrin Subunit Beta 7

Function

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Biological Process

Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cell-matrix adhesion involved in ameboidal cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Heterotypic cell-cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Leukocyte tethering or rollingManual Assertion Based On ExperimentIMP:UniProtKB
Receptor clusteringManual Assertion Based On ExperimentIMP:UniProtKB
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB
T cell migrationIEA:Ensembl

Cellular Location

Membrane

Topology

Extracellular: 20-723
Helical: 724-746
Cytoplasmic: 747-798

More Infomation

References

Yang, L., Wang, M., Yuan, L., Chen, S., Peng, S., Yang, P., ... & He, X. (2022). EccDNA-oriented ITGB7 expression in breast cancer. Annals of Translational Medicine, 10(24).

Xu, T., Liu, J., Xia, Y., Wang, Z., Li, X., & Gao, Q. (2021). Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis. Annals of Medicine, 53(1), 916-928.

Baran, A., Nowowiejska, J., Kamiński, T. W., Krahel, J. A., & Flisiak, I. (2021). Circulating MAdCAM-1 and ITGB7 in patients with plaque psoriasis and eruptive lichen planus—Preliminary data. Biology, 10(11), 1129.

Sun, Q., Ye, Z., Qin, Y., Fan, G., Ji, S., Zhuo, Q., ... & Yu, X. (2020). Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis. Oncogene, 39(42), 6572-6588.

Kawabata, Y., Nishida, N., Awata, T., Kawasaki, E., Imagawa, A., Shimada, A., ... & Ikegami, H. (2019). Genome-wide association study confirming a strong effect of HLA and identifying variants in CSAD/lnc-ITGB7-1 on chromosome 12q13. 13 associated with susceptibility to fulminant type 1 diabetes. Diabetes, 68(3), 665-675.

Chai, Z., Yang, Y., Gu, Z., Cai, X., Ye, W., Kong, L., ... & Wang, L. (2019). Recombinant viral capsid protein L2 (rVL2) of HPV 16 suppresses cell proliferation and glucose metabolism via ITGB7/C/EBPβ signaling pathway in cervical cancer cell lines. OncoTargets and therapy, 12, 10415.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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