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Mouse Anti-IRF9 Antibody (2B7) (CBMAB-0554-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2B7
Antibody Isotype
IgG2b
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
IRF9
Introduction
IRF9 (interferon regulatory factor 9) is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G. IRF9 has been shown to interact with STAT2 and STAT1.
Entrez Gene ID
10379
UniProt ID
Q00978
Alternative Names
p48; IRF-9; ISGF3; ISGF3G
Function
Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Biological Process
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Defense response to virusIEA:UniProtKB-KW
Immune system processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm; Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
Involvement in disease
Immunodeficiency 65 (IMD65):
An autosomal recessive immunologic disorder characterized by recurrent viral infections from early infancy. Clinical consequences are pneumonia, bronchiectasis, and septic shock. Affected individuals have lymphopenia or hypogammaglobulinemia, particularly during infection, and impaired cellular type I interferon response. Patients may have adverse response to vaccination with live attenuated vaccines.
PTM
(Microbial infection) Ubiquitinated by Herpes simplex virus 2 E3 ubiquitin ligase ICP22.
More Infomation

Drury, S., Claussen, G., Zetterman, A., Moriyama, H., Moriyama, E. N., & Zhang, L. (2023). Evolution and emergence of primate‐specific interferon regulatory factor 9. Journal of Medical Virology, 95(2), e28521.

Paul, A., Ismail, M. N., Tang, T. H., & Ng, S. K. (2023). Phosphorylation of interferon regulatory factor 9 (IRF9). Molecular biology reports, 50(4), 3909-3917.

Li, L., Fu, J., Li, J., Guo, S., Chen, Q., Zhang, Y., ... & Wang, X. (2022). African swine fever virus pI215L inhibits type I interferon signaling by targeting interferon regulatory factor 9 for Autophagic degradation. Journal of Virology, 96(17), e00944-22.

Gothe, F., Spegarova, J. S., Hatton, C. F., Griffin, H., Sargent, T., Cowley, S. A., ... & Hambleton, S. (2022). Aberrant inflammatory responses to type I interferon in STAT2 or IRF9 deficiency. Journal of Allergy and Clinical Immunology, 150(4), 955-964.

Brunn, D., Turkowski, K., Günther, S., Weigert, A., Muley, T., Kriegsmann, M., ... & Savai, R. (2021). Interferon regulatory factor 9 promotes lung cancer progression via regulation of versican. Cancers, 13(2), 208.

Li, W., Deng, P., Wang, J., Li, Z., & Zhang, H. (2020). MiR-17 knockdown promotes vascular smooth muscle cell phenotypic modulation through upregulated interferon regulator Factor 9 expression. American Journal of Hypertension, 33(12), 1119-1126.

Zhu, Y., Shan, S., Feng, H., Jiang, L., An, L., Yang, G., & Li, H. (2019). Molecular characterization and functional analysis of interferon regulatory factor 9 (irf9) in common carp Cyprinus carpio: a pivotal molecule in the Ifn response against pathogens. Journal of Fish Biology, 95(2), 510-519.

Paul, A., Tang, T. H., & Ng, S. K. (2018). Interferon regulatory factor 9 structure and regulation. Frontiers in immunology, 9, 1831.

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For research use only. Not intended for any clinical use.

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