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Mouse Anti-IRF6 Recombinant Antibody (2C10) (CBMAB-I0703-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Rat, Dog
Clone
2C10
Antibody Isotype
IgG1
Application
WB, FC, IHC, IF, IHC-P

Basic Information

Specificity
Human, Rat, Dog
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interferon Regulatory Factor 6
Introduction
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
Human3664
Rat364081
Dog480015
UniProt ID
HumanO14896
RatD4AAV0
DogE2QSS0
Alternative Names
Interferon Regulatory Factor 6
Function
Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity).
Plays a role in regulating mammary epithelial cell proliferation (By similarity).
May regulate WDR65 transcription (By similarity).
Biological Process
Cell developmentIEA:Ensembl
Cranial skeletal system developmentIEA:Ensembl
Immune system processManual Assertion Based On ExperimentIBA:GO_Central
Keratinocyte differentiationIEA:Ensembl
Keratinocyte proliferationIEA:Ensembl
Limb developmentIEA:Ensembl
Mammary gland epithelial cell differentiationISS:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Roof of mouth developmentIEA:Ensembl
Cellular Location
Cytoplasm; Nucleus. Translocates to nucleus in response to an activating signal.
Involvement in disease
Van der Woude syndrome 1 (VWS1):
An autosomal dominant developmental disorder characterized by lower lip pits, cleft lip and/or cleft palate.
Popliteal pterygium syndrome (PPS):
An autosomal dominant disorder characterized by oro-facial, skin and genital anomalies. Expressivity is variable. Clinical features include cleft lip/palate, lower lip cysts, syngnathia, congenital ankyloblepharon filiforme in some cases, bifid scrotum, hypoplastic scrotum, hypoplastic uterus, talipes equinovarus.
Non-syndromic orofacial cleft 6 (OFC6):
A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
PTM
Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation.
More Infomation

Liang, Y., Liu, R., Zhang, J., Chen, Y., Shan, S., Zhu, Y., ... & Li, H. (2022). Negative regulation of interferon regulatory factor 6 (IRF6) in interferon and NF-κB signalling pathways of common carp (Cyprinus carpio L.). BMC veterinary research, 18(1), 1-12.

Tan, L., Qu, W., Wu, D., Liu, M., Ai, Q., Hu, H., ... & Zhou, H. (2022). The interferon regulatory factor 6 promotes cisplatin sensitivity in colorectal cancer. Bioengineered, 13(4), 10504-10517.

Liu, Y., Shao, G., Yang, Z., Lin, X., Liu, X., Qian, B., & Liu, Z. (2021). Interferon regulatory factor 6 correlates with the progression of non-small cell lung cancer and can be regulated by miR-320. Journal of Pharmacy and Pharmacology, 73(5), 682-691.

Li, Z., Yang, W., Qiu, J., Xu, H., Fan, B., Li, K., ... & Li, Y. (2021). Decreased interferon regulatory factor 6 expression due to DNA hypermethylation predicts an unfavorable prognosis in clear cell renal cell carcinoma. Journal of Cancer, 12(22), 6640.

Ren, Y., Dong, J., He, P., Liang, Y., Wu, L., Wang, J., & Chu, B. (2020). miR‐587 promotes cervical cancer by repressing interferon regulatory factor 6. The journal of gene medicine, 22(11), e3257.

Rhea, L., Canady, F. J., Le, M., Reeb, T., Canady, J. W., Kacmarynski, D. S., ... & Dunnwald, M. (2020). Interferon regulatory factor 6 is required for proper wound healing in vivo. Developmental Dynamics, 249(4), 509-522.

Tong, J., Han, C. J., Zhang, J. Z., He, W. Z., Zhao, G. J., Cheng, X. U., ... & Li, H. (2019). Hepatic interferon regulatory factor 6 alleviates liver steatosis and metabolic disorder by transcriptionally suppressing peroxisome proliferator‐activated receptor γ in mice. Hepatology, 69(6), 2471-2488.

Metwalli, K. A., Do, M. A., Nguyen, K., Mallick, S., Kin, K., Farokhnia, N., ... & Fakhouri, W. D. (2018). Interferon regulatory factor 6 is necessary for salivary glands and pancreas development. Journal of dental research, 97(2), 226-236.

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For research use only. Not intended for any clinical use.

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