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Mouse Anti-IL2RA Recombinant Antibody (B-G3) (CBMAB-I2009-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
B-G3
Antibody Isotype
IgG1
Application
FC, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 2 Receptor Subunit Alpha
Introduction
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Entrez Gene ID
3559
UniProt ID
P01589
Alternative Names
CD25; Il2r; Ly-43
Function
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Biological Process
Activation-induced cell death of T cellsIEA:Ensembl
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory response to antigenic stimulusIEA:Ensembl
Negative regulation of inflammatory responseIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Notch signaling pathwayIEA:Ensembl
Positive regulation of activated T cell proliferationIEA:Ensembl
Positive regulation of T cell differentiationIEA:Ensembl
Regulation of T cell homeostatic proliferationIEA:Ensembl
Regulation of T cell tolerance inductionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane
Involvement in disease
Diabetes mellitus, insulin-dependent, 10 (IDDM10):
A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41):
A disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions.
Topology
Extracellular: 22-240
Helical: 241-259
Cytoplasmic: 260-272
More Infomation

Gil-Quiñones, S. R., Sepúlveda-Pachón, I. T., Sánchez Vanegas, G., & Gutierrez-Castañeda, L. D. (2021). Effect of PTPN22, FAS/FASL, IL2RA and CTLA4 genetic polymorphisms on the risk of developing alopecia areata: A systematic review of the literature and meta-analysis. PLoS One, 16(11), e0258499.

Joosse, M. E., Charbit-Henrion, F., Boisgard, R., Lindenbergh-Kortleve, D. J., Costes, L. M., Nugteren, S., ... & Samsom, J. N. (2021). Duplication of the IL2RA locus causes excessive IL-2 signaling and may predispose to very early onset colitis. Mucosal Immunology, 14(5), 1172-1182.

Borysewicz-Sańczyk, H., Sawicka, B., Wawrusiewicz-Kurylonek, N., Głowińska-Olszewska, B., Kadłubiska, A., Gościk, J., ... & Bossowski, A. (2020). Genetic association study of IL2RA, IFIH1, and CTLA-4 polymorphisms with autoimmune thyroid diseases and type 1 diabetes. Frontiers in pediatrics, 8, 481.

Nguyen, C. H., Schlerka, A., Grandits, A. M., Koller, E., van der Kouwe, E., Vassiliou, G. S., ... & Wieser, R. (2020). IL2RA promotes aggressiveness and stem cell–related properties of acute myeloid Leukemia. Cancer research, 80(20), 4527-4539.

Du, W., He, J., Zhou, W., Shu, S., Li, J., Liu, W., ... & Hu, D. (2019). High IL2RA mRNA expression is an independent adverse prognostic biomarker in core binding factor and intermediate-risk acute myeloid leukemia. Journal of translational medicine, 17, 1-14.

Jia, Z., Zhang, Z., Yang, Q., Deng, C., Li, D., & Ren, L. (2019). Effect of IL2RA and IL2RB gene polymorphisms on lung cancer risk. International immunopharmacology, 74, 105716.

de Oyarzabal, E., García-García, L., Rangel-Escareño, C., Ferreyra-Reyes, L., Orozco, L., Herrera, M. T., ... & Torres, M. (2019). Expression of USP18 and IL2RA is increased in individuals receiving latent tuberculosis treatment with isoniazid. Journal of Immunology Research, 2019.

Wang, X. X., & Chen, T. (2018). Meta-analysis of the association of IL2RA polymorphisms rs2104286 and rs12722489 with multiple sclerosis risk. Immunological investigations, 47(5), 431-442.

Belot, M. P., Castell, A. L., Le Fur, S., & Bougnères, P. (2018). Dynamic demethylation of the IL2RA promoter during in vitro CD4+ T cell activation in association with IL2RA expression. Epigenetics, 13(5), 459-472.

Xia, Z. L., Qin, Q. M., & Zhao, Q. Y. (2018). A genetic link between CXCR5 and IL2RA gene polymorphisms and susceptibility to multiple sclerosis. Neurological Research, 40(12), 1040-1047.

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For research use only. Not intended for any clinical use.

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