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Rabbit Anti-IGF2R Recombinant Antibody (CBYY-I1667) (CBMAB-I2837-YY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
CBYY-I1667
Application
WB, IP, IF

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Insulin Like Growth Factor 2 Receptor
Introduction
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).
Entrez Gene ID
Human3482
Mouse16004
Rat25151
Monkey703220
UniProt ID
HumanP11717
MouseQ07113
RatG3V824
MonkeyF6RDI1
Alternative Names
Insulin Like Growth Factor 2 Receptor
Function
Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523).

Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523).

The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523).

This receptor also binds IGF2 (PubMed:18046459).

Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005).
Biological Process
Animal organ regeneration Source: Ensembl
G protein-coupled receptor signaling pathway Source: Ensembl
Liver development Source: Ensembl
Lysosomal transport Source: InterPro
Positive regulation by host of viral process Source: ARUK-UCL
Positive regulation of apoptotic process Source: Ensembl
Post-embryonic development Source: Ensembl
Receptor-mediated endocytosis Source: ProtInc
Response to retinoic acid Source: Ensembl
Response to tetrachloromethane Source: Ensembl
Signal transduction Source: ProtInc
Spermatogenesis Source: Ensembl
Cellular Location
Endosome membrane; Golgi apparatus membrane. Mainly localized in the Golgi at steady state and not detectable in lysosome (PubMed:18817523). Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005).
Topology
Lumenal: 41-2304
Helical: 2305-2327
Cytoplasmic: 2328-2491
PTM
Palmitoylated (PubMed:18817523). Undergoes cysteine S-palmitoylation which promotes interaction with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus (PubMed:18817523).
More Infomation

Yuan, D., Guo, T., Qian, H., Ge, H., Zhao, Y., Huang, A., ... & Yu, H. (2022). Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR‐144‐3p/IGF2R axis. Drug Development Research, 83(6), 1383-1393.

Han, J., Goldstein, L. A., Hou, W., Watkins, S. C., & Rabinowich, H. (2021). Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport. Autophagy, 17(6), 1393-1409.

Zhang, Z., Mou, Z., Xu, C., Wu, S., Dai, X., Chen, X., ... & Jiang, H. (2021). Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation. Cell Death & Disease, 12(8), 778.

Liu, L., He, L., Li, W., Zhao, T., Li, G., Xiu, X., ... & Zhong, Q. (2021). The miR-4306/IGF2R axis modulates the lung adenocarcinoma response to irradiation in vitro and in vivo. Translational Lung Cancer Research, 10(12), 4494.

Pluvinage, J. V., Sun, J., Claes, C., Flynn, R. A., Haney, M. S., Iram, T., ... & Wyss-Coray, T. (2021). The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C. Science translational medicine, 13(622), eabg2919.

Lin, X., Du, Y., Lu, W., Gui, W., Sun, S., Zhu, Y., ... & Li, H. (2021). CircRNF111 protects against insulin resistance and lipid deposition via regulating miR-143-3p/IGF2R axis in metabolic syndrome. Frontiers in Cell and Developmental Biology, 9, 663148.

Choi, Y. J., Lee, Y. A., Hong, Y. C., Cho, J., Lee, K. S., Shin, C. H., ... & Lim, Y. H. (2020). Effect of prenatal bisphenol A exposure on early childhood body mass index through epigenetic influence on the insulin-like growth factor 2 receptor (IGF2R) gene. Environment International, 143, 105929.

Wang, X., Lin, L., Lan, B., Wang, Y., Du, L., Chen, X., ... & Wang, Y. (2020). IGF2R-initiated proton rechanneling dictates an anti-inflammatory property in macrophages. Science Advances, 6(48), eabb7389.

Takeda, T., Komatsu, M., Chiwaki, F., Komatsuzaki, R., Nakamura, K., Tsuji, K., ... & Sasaki, H. (2019). Upregulation of IGF2R evades lysosomal dysfunction-induced apoptosis of cervical cancer cells via transport of cathepsins. Cell Death & Disease, 10(12), 876.

Karkare, S., Allen, K. J., Jiao, R., Malo, M. E., Dawicki, W., Helal, M., ... & Dadachova, E. (2019). Detection and targeting insulin growth factor receptor type 2 (IGF2R) in osteosarcoma PDX in mouse models and in canine osteosarcoma tumors. Scientific reports, 9(1), 11476.

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For research use only. Not intended for any clinical use.

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