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Mouse Anti-ID4 Recombinant Antibody (3F11) (CBMAB-A4218-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3F11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
ID4 (NP_001537.1, 1 a.a. ~ 161 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
inhibitor of DNA binding 4, HLH protein
Introduction
Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995 [PubMed 7665172]).[supplied by OMIM
Entrez Gene ID
3400
UniProt ID
P47928
Alternative Names
IDB4; bHLHb27
Function
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).
Biological Process
Cell differentiation Source: GO_Central
Cellular protein localization Source: Ensembl
Central nervous system myelination Source: Ensembl
Cerebral cortex neuron differentiation Source: Ensembl
Circadian regulation of gene expression Source: GO_Central
Fat cell differentiation Source: Ensembl
G1/S transition of mitotic cell cycle Source: Ensembl
Hippocampus development Source: Ensembl
Negative regulation of astrocyte differentiation Source: Ensembl
Negative regulation of fat cell differentiation Source: Ensembl
Negative regulation of neuron differentiation Source: Ensembl
Negative regulation of oligodendrocyte differentiation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: GDB
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Neuroblast proliferation Source: Ensembl
Osteoblast differentiation Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Prostate gland epithelium morphogenesis Source: Ensembl
Prostate gland stromal morphogenesis Source: Ensembl
Seminal vesicle morphogenesis Source: Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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