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Mouse Anti-ICAM3 Recombinant Antibody (A368) (CBMAB-AP3522LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
A368
Antibody Isotype
IgG1, κ
Application
ELISA, FC, ICC, IHC, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Intercellular Adhesion Molecule 3
Introduction
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Entrez Gene ID
3385
UniProt ID
P32942
Alternative Names
Intercellular Adhesion Molecule 3
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173).

ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Biological Process
Cell adhesion Source: GO_Central
Cell-cell adhesion Source: InterPro
Phagocytosis Source: UniProtKB-KW
Cellular Location
Membrane
Topology
Extracellular: 30-485
Helical: 486-510
Cytoplasmic: 511-547
PTM
Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.
More Infomation

Li, L., Yang, C., Aruna, Zhou, Q., Jiang, X., Du, W., ... & Shen, W. (2022). Functional evaluation of various ICAM3 transcript variants in diffuse large B-Cell lymphoma. Leukemia & Lymphoma, 63(12), 2869-2878.

Zicheng, H., Xiao, Y., Rongzhong, H., Yongyong, L., Haitao, R., & Tingting, S. (2021). Association of Circulating ICAM3 Concentrations with Severity and Short-term Outcomes of Acute Ischemic Stroke. Neurotoxicity Research, 39(4), 1293-1299.

Chen, W. Y., Wu, S. Y., Lin, T. C., Lin, S. L., & Wu-Hsieh, B. A. (2019). Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis. Cellular & Molecular Immunology, 16(3), 288-301.

Demiryürek, S., Saracaloglu, A., Kimyon, S., Mete, A., Eronat, O., Temiz, E., ... & Demiryürek, A. T. (2019). Increased Expressions of ICAM-2 and ICAM-3 in Pterygium. Current eye research, 44(6), 645-650.

Cruz, L. J., Tacken, P. J., van der Schoot, J. M., Rueda, F., Torensma, R., & Figdor, C. G. (2019). ICAM3-Fc outperforms receptor-specific antibodies targeted nanoparticles to dendritic cells for cross-presentation. Molecules, 24(9), 1825.

Velasquez, L. N., Stüve, P., Gentilini, M. V., Swallow, M., Bartel, J., Lycke, N. Y., ... & Berod, L. (2018). Targeting Mycobacterium tuberculosis antigens to dendritic cells via the DC-specific-ICAM3-grabbing-nonintegrin receptor induces strong T-helper 1 immune responses. Frontiers in immunology, 9, 471.

Chéneau, C., Coulon, F., Porkolab, V., Fieschi, F., Laurant, S., Razanajaona-Doll, D., ... & Halary, F. (2018). Fine mapping the interaction between dendritic cell-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin and the cytomegalovirus envelope glycoprotein B. The Journal of Infectious Diseases, 218(3), 490-503.

Shen, W., Xie, J., Zhao, S., Du, R., Luo, X., He, H., ... & Luo, Y. (2018). ICAM3 mediates inflammatory signaling to promote cancer cell stemness. Cancer letters, 422, 29-43.

Shen, W., Zhang, X., Du, R., Fan, Y., Luo, D., Bao, Y., ... & Zhao, S. (2018). ICAM3 mediates tumor metastasis via a LFA-1-ICAM3-ERM dependent manner. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(8), 2566-2578.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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