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Mouse Anti-ICAM3 Recombinant Antibody (A364) (CBMAB-AP3536LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
A364
Antibody Isotype
IgG1, κ
Application
FC, IHC, IP

Basic Information

Immunogen
B cell lymphoma cells
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Intercellular Adhesion Molecule 3
Introduction
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Entrez Gene ID
3385
UniProt ID
P32942
Alternative Names
Intercellular Adhesion Molecule 3
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173).

ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Biological Process
Cell adhesion Source: GO_Central
Cell-cell adhesion Source: InterPro
Phagocytosis Source: UniProtKB-KW
Cellular Location
Membrane
Topology
Extracellular: 30-485
Helical: 486-510
Cytoplasmic: 511-547
PTM
Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.
More Infomation

Li, L., Yang, C., Aruna, Zhou, Q., Jiang, X., Du, W., ... & Shen, W. (2022). Functional evaluation of various ICAM3 transcript variants in diffuse large B-Cell lymphoma. Leukemia & Lymphoma, 63(12), 2869-2878.

Zicheng, H., Xiao, Y., Rongzhong, H., Yongyong, L., Haitao, R., & Tingting, S. (2021). Association of Circulating ICAM3 Concentrations with Severity and Short-term Outcomes of Acute Ischemic Stroke. Neurotoxicity Research, 39(4), 1293-1299.

Chen, W. Y., Wu, S. Y., Lin, T. C., Lin, S. L., & Wu-Hsieh, B. A. (2019). Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis. Cellular & Molecular Immunology, 16(3), 288-301.

Demiryürek, S., Saracaloglu, A., Kimyon, S., Mete, A., Eronat, O., Temiz, E., ... & Demiryürek, A. T. (2019). Increased Expressions of ICAM-2 and ICAM-3 in Pterygium. Current eye research, 44(6), 645-650.

Cruz, L. J., Tacken, P. J., van der Schoot, J. M., Rueda, F., Torensma, R., & Figdor, C. G. (2019). ICAM3-Fc outperforms receptor-specific antibodies targeted nanoparticles to dendritic cells for cross-presentation. Molecules, 24(9), 1825.

Velasquez, L. N., Stüve, P., Gentilini, M. V., Swallow, M., Bartel, J., Lycke, N. Y., ... & Berod, L. (2018). Targeting Mycobacterium tuberculosis antigens to dendritic cells via the DC-specific-ICAM3-grabbing-nonintegrin receptor induces strong T-helper 1 immune responses. Frontiers in immunology, 9, 471.

Chéneau, C., Coulon, F., Porkolab, V., Fieschi, F., Laurant, S., Razanajaona-Doll, D., ... & Halary, F. (2018). Fine mapping the interaction between dendritic cell-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin and the cytomegalovirus envelope glycoprotein B. The Journal of Infectious Diseases, 218(3), 490-503.

Shen, W., Xie, J., Zhao, S., Du, R., Luo, X., He, H., ... & Luo, Y. (2018). ICAM3 mediates inflammatory signaling to promote cancer cell stemness. Cancer letters, 422, 29-43.

Shen, W., Zhang, X., Du, R., Fan, Y., Luo, D., Bao, Y., ... & Zhao, S. (2018). ICAM3 mediates tumor metastasis via a LFA-1-ICAM3-ERM dependent manner. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(8), 2566-2578.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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