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Rabbit Anti-HTR5A Recombinant Antibody (EG1593) (CBMAB-EN1906-LY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1593
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human 5-HT-5A.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
5-Hydroxytryptamine Receptor 5A
Introduction
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3361
UniProt ID
P47898
Alternative Names
5-Hydroxytryptamine Receptor 5A; 5-Hydroxytryptamine (Serotonin) Receptor 5A, G Protein-Coupled; 5-HT-5A; 5-HT-5; 5-HT5A; 5-Hydroxytryptamine (Serotonin) Receptor 5A; Serotonin Receptor 5A;
Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Hippocampus development Source: Ensembl
Response to estradiol Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-40
Helical: 41-63
Cytoplasmic: 64-78
Helical: 79-99
Extracellular: 100-115
Helical: 116-137
Cytoplasmic: 138-158
Helical: 159-181
Extracellular: 182-198
Helical: 199-219
Cytoplasmic: 220-282
Helical: 283-303
Extracellular: 304-320
Helical: 321-341
Cytoplasmic: 342-357
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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