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Rabbit Anti-HTR1E Recombinant Antibody (CBLQ5-012) (CBMAB-1965CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBLQ5-012
Antibody Isotype
IgG
Application
WB, IHC-P, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
5-Hydroxytryptamine Receptor 1E
Introduction
Serotonin (5-hydroxytryptamine; 5-HT) is a neurotransmitter thought to play a role in various cognitive and behavioral functions including feeding, sleep, pain, depression, and learning. Serotonin receptors have been divided into classes depending on their ligand binding and effector-coupling properties. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Entrez Gene ID
3354
UniProt ID
P28566
Alternative Names
5-HT1E
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-22
Helical: 23-47
Cytoplasmic: 48-59
Helical: 60-82
Extracellular: 83-96
Helical: 97-118
Cytoplasmic: 119-138
Helical: 139-159
Extracellular: 160-179
Helical: 180-202
Cytoplasmic: 203-291
Helical: 292-314
Extracellular: 315-324
Helical: 325-347
Cytoplasmic: 348-365
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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